Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome

Table 1 Clinical data

Parameter	Observation group, n = 73	Control group, n = 64	X2/t	P value
Sex			0.456	0.499
Male	38 (52.05)	37 (57.81)
Female	35 (47.95)	27 (42.19)
Gestational age in wk	33.37 ± 2.12	32.87 ± 2.05	1.399	0.164
Body mass in kg	2.82 ± 0.69	2.71 ± 0.58	1.002	0.318
Apgar score	8.47 ± 1.31	8.28 ± 1.26	0.862	0.390
Age of pregnant woman in yr	27.3 ± 4.8	26.5 ± 4.1	1.041	0.230
Hypertension of Pregnant Women	9 (12.33)	5 (7.81)	0.758	0.384
Diabetes of pregnant women	11 (15.07)	7 (10.94)	0.510	0.475
Premature rupture of membranes	9 (12.33)	10 (15.63)	0.310	0.578
Delivery mode			0.566	0.452
Eutocia	41 (56.16)	40 (62.50)
Cesarean section	32 (43.84)	24 (37.50)
Premature delivery			0.804	0.370
Yes	52 (71.23)	41 (64.06)
No	21 (28.77)	23 (35.94)
Delivery history			0.027	0.870
Primiparity	50 (68.49)	43 (67.19)
Multiparity	23 (31.51)	21 (32.81)

Table 2 Effective therapy and adverse reactions

Outcome	Observation group, n = 73	Control group, n = 64	t	P value
Effective curative effect	67 (91.78)	51 (79.69)	4.175	0.041
Ineffective curative effect	6 (8.22)	13 (20.31)
Death	3 (4.11)	6 (9.38)	1.540	0.215
Bronchial dysplasia	6 (8.22)	11 (17.19)	2.514	0.112
Cyanopathy	8 (10.96)	10 (15.63)	0.651	0.420
Shortness of breath	9 (12.33)	14 (21.88)	2.225	0.136

Table 3 Receiver operating characteristic curve analysis

Index	AUC	95%CI	Specificity, %	Sensitivity, %	Youden index, %	Cut-off
KRT-14	0.791	0.665-0.917	85.47	60.00	45.47	> 3.645
ET-1	0.816	0.726-0.907	76.07	70.00	46.07	> 40.060

AUC: Area under the curve; ET-1: Endothelin-1; KRT-14: Keratin-14.