Shi ZN, Zhang X, Du CY, Zhao B, Liu SG. Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome. World J Clin Cases 2024; 12(23): 5366-5373 [DOI: 10.12998/wjcc.v12.i23.5366]
Corresponding Author of This Article
Xin Zhang, PhD, Research Fellow, Department of Anesthesiology, Army Military Medical University Officer School Affiliated Hospital, No. 346 Shenglibei Street, Shijiazhuang 050000, Hebei Province, China. zhangxing202309@163.com
Research Domain of This Article
Health Care Sciences & Services
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 16, 2024; 12(23): 5366-5373 Published online Aug 16, 2024. doi: 10.12998/wjcc.v12.i23.5366
Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome
Ze-Ning Shi, Xin Zhang, Chun-Yuan Du, Bing Zhao, Shu-Gang Liu
Ze-Ning Shi, Shu-Gang Liu, Department of Pediatrics, Army Military Medical University Officer School Affiliated Hospital, Shijiazhuang 050000, Hebei Province, China
Xin Zhang, Bing Zhao, Department of Anesthesiology, Army Military Medical University Officer School Affiliated Hospital, Shijiazhuang 050000, Hebei Province, China
Chun-Yuan Du, Department of Gynecology and Obstetrics, Army Military Medical University Officer School Affiliated Hospital, Shijiazhuang 050000, Hebei Province, China
Author contributions: Shi ZN, Zhang X, and Du CY were the guarantors of the integrity of the entire study; Zhang X and Zhao B performed the study concept and design; Shi ZN and Liu SG performed the literature study; Shi ZN and Zhang Xin pro conducted the study; Shi ZN and Zhang X conducted the statistical analysis; Shi ZN and Zhang X wrote the manuscript; All authors have access to the data and played a role in writing this manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the Hospital affiliated to the Military Medical University (Approval No. 2024007).
Informed consent statement: As this study was retrospective, informed consent of patients was not required.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Data sharing statement: Data for this study were obtained from the corresponding authors.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Zhang, PhD, Research Fellow, Department of Anesthesiology, Army Military Medical University Officer School Affiliated Hospital, No. 346 Shenglibei Street, Shijiazhuang 050000, Hebei Province, China. zhangxing202309@163.com
Received: March 22, 2024 Revised: May 25, 2024 Accepted: June 12, 2024 Published online: August 16, 2024 Processing time: 104 Days and 18.7 Hours
Core Tip
Core Tip: The purpose of this study was to explore the effect of pulmonary surfactant (PS) combined with noninvasive positive pressure ventilation on the levels of keratin-14 (KRT-14) and endothelin-1 (ET-1) in peripheral blood and the effectiveness for treating neonatal respiratory distress syndrome (NRDS). KRT-14 and ET-1 expression in the two groups was compared. The therapeutic effectiveness, occurrence of death and complications, and the blood gas indexes PaO2, PaCO2 and PaO2/FiO2 in the two groups were compared. Receiver operating characteristic curve analysis was used to determine the diagnostic value of KRT-14 and ET-1 for the effectiveness of NRDS therapy. PS combined with noninvasive positive pressure ventilation significantly improved the effectiveness of NRDS therapy. KRT-14 and ET-1 levels may have potential as diagnostic indicators of therapy.
