Goblet cell carcinoid of the appendix: Six case reports

Table 1 Details of the 6 cases

Feature	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6
Sex	Male	Female	Female	Male	Male	Male
Age in year	44	50	50	72	47	69
BMI in kg/m2	22.8	32	22.1	25	27.1	23.2
Chief complaint	Vomiting	Abdominal pain	Abdominal pain	Abdominal pain	Abdominal pain	Abdominal pain
Laboratory data at 1st visit
WBC as /mm3	5190	17060	8100	12510	19480	15830
CRP in mg/dL	1.01	0.21	0.01	14.2	12.2	5.9
CEA in ng/mL	2.2	2.1	2.2	4	1.2	5.7
CA19-9 in U/mL	5.2	5.7	7.6	< 0.4	5.6	3.9
Colonoscopy before operation (biopsy)	Edematous mucosa of cecum (+)	-	-	-	-	-
Maximum minor diameter of appendix on CT in mm	9	8	9	20	19	17
Initial diagnosis	GCC	Appendicitis	Appendix tumor	Appendicitis	Appendicitis	Appendicitis
1st operation	ICR (open)	Appendectomy	Appendectomy	Appendectomy	Appendectomy	Appendectomy
Colonoscopy before 2nd operation (biopsy)	-	Wnl (-)	-	Wnl (-)	Wnl (-)	-
2nd operation	-	ICR (lap)	ICR (lap)	ICR (open)	ICR (lap)	ICR (lap)
Lymph node dissection	D3	D3	D3	D3	D3	D3
T factor	4a	3	3	3	3	3
N factor	1b	0	1a	0	0	0
Stage by AJCC	IIIB	IIA	IIIB	IIA	IIA	IIA
Tumor size in mm	70	15	22	50	12	27
Adjuvant chemotherapy	FOLFOX	-	CAPOX	-	-	-
Outcomes (follow-up in mo)	RFS (56)	RFS (30)	RFS (18)	RFS (12)	RFS (6)	RFS (2)

AJCC: American Joint Committee on Cancer; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; CRP: C-reactive protein; CT: Computed tomography; GCC: Goblet cell carcinoid; ICR: Ileocecal resection; lap: Laparoscopic surgery; RFS: Recurrence-free survival; WBC: White blood cell count; Wnl: Within normal limit.

Table 2 Previously reported articles about goblet cell carcinoid

Ref.	Cases	Median age in yr (range)	Sex as male/female	Stage I/II/III/IV by AJCC	Colectomy, %	5-yr OS, %	MST in mo
Pham et al[15]	57	55 (mean)	21/36	8/20/6/23	NA	45	47
Tang et al[4]	63	49 (29-80)	20/43	2/18/3/40	57 (75)	58	43
Olsen et al[19]	83	59 (31-77)	56/27	12/35/3/27	69 (83)	58	83
Lamarca et al[20]	74	56 (26-83)	34/40	2/29/12/28	42 (57)	48	52
Nonaka et al[21]	105	54 (25-79)	54/51	5/52/13/35	45 (43)	NA	67
Tsang et al[22]	86	54 (25-91)	42/44	67 (I-III)/19	51 (76)	68	NA

AJCC: American Joint Committee on Cancer; MST: Median survival time; NA: Not available; OS: Overall survival.