Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2024; 12(22): 5217-5224
Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5217
Goblet cell carcinoid of the appendix: Six case reports
Toshiaki Toshima, Ryo Inada, Shinya Sakamoto, Eri Takeda, Takahiro Yoshioka, Kento Kumon, Naoki Mimura, Nobuo Takata, Motoyasu Tabuchi, Kazuyuki Oishi, Takuji Sato, Kenta Sui, Takehiro Okabayashi, Kazuhide Ozaki, Toshio Nakamura, Yuichi Shibuya, Manabu Matsumoto, Jun Iwata
Toshiaki Toshima, Ryo Inada, Shinya Sakamoto, Eri Takeda, Takahiro Yoshioka, Kento Kumon, Naoki Mimura, Nobuo Takata, Motoyasu Tabuchi, Kazuyuki Oishi, Takuji Sato, Kenta Sui, Takehiro Okabayashi, Kazuhide Ozaki, Toshio Nakamura, Yuichi Shibuya, Department of Gastroenterological Surgery, Kochi Health Sciences Center, Kochi 781-8555, Japan
Manabu Matsumoto, Jun Iwata, Department of Diagnostic Pathology, Kochi Health Sciences Center, Kochi 781-8555, Japan
Author contributions: Toshima T and Inada R designed study, developed the main conceptual ideas, and wrote the manuscript; Toshima T, Sakamoto S, Takeda E, Yoshioka T, Kumon K, and Mimura N collected the data; Inada R, Oishi K, Sato T, Sui K, Okabayashi T, Ozaki K, Nakamura T, and Shibuya Y aided in interpreting the results; Takata N and Tabuchi M helped with the sentence structure; Matsumoto M and Iwata J reviewed the pathology; All authors have read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ryo Inada, MD, PhD, Director, Doctor, Department of Gastrointestinal Surgery, Kochi Health Sciences Center, 2125-1 Ike, Kochi 781-8555, Japan. ryo_inada@hotmail.com
Received: April 11, 2024
Revised: May 21, 2024
Accepted: May 30, 2024
Published online: August 6, 2024
Processing time: 81 Days and 22.4 Hours
Core Tip

Core Tip: Diagnosing goblet cell carcinoid (GCC) of the appendix preoperatively is very difficult, because most patients with a chief complaint of acute abdomen undergo appendectomy based on a preoperative diagnosis of appendicitis. Even if colonoscopy is performed, accurate endoscopic diagnosis is very difficult because GCCs show a submucosal growth pattern with invasion of the appendiceal wall. The possibility of GCC must always be kept in mind during surgical treatment for presumptive appendicitis. This report includes an extremely rare example of correct preoperative diagnosis of appendiceal GCC.