Association between gut microbiota and hepatocellular carcinoma and biliary tract cancer: A mendelian randomization study

Table 1 Causal associations between genetically predicted 13 microbial taxa and hepatocellular carcinoma and biliary tract cancer

Outcome	Exposure	Method	nSNP	β	SE	OR (95%CI)	P value
Biliary tract cancer
	Genus Eubacterium hallii group	IVW	11	0.838	0.351	2.31 (1.16-4.61)	0.017
	Genus Candidatus Soleaferrea	IVW	9	0.802	0.377	2.23 (1.06-4.67)	0.034
	Genus Dorea	IVW	7	-1.232	0.603	0.29 (0.09-0.95)	0.041
	Genus Flavonifractor	IVW	5	1.619	0.702	5.05 (1.27-19.9)	0.021
	Genus Lachnospiraceae FCS020 group	IVW	11	0.710	0.335	2.03 (1.06-3.92)	0.034
	Genus Lachnospiraceae ND3007 group	IVW	3	-2.430	1.214	0.09 (0.01-0.95)	0.045
	Order Victivallales	IVW	6	0.791	0.334	2.21 (1.15-4.25)	0.018
	Class Lentisphaeria	IVW	6	0.791	0.334	2.21 (1.15-4.25)	0.018
Hepatocellular carcinoma
	Genus Desulfovibrio	IVW	9	0.324	0.159	1.38 (1.01-1.89)	0.042
	Genus Oscillibacter	IVW	9	0.345	0.151	1.41 (1.05-1.90)	0.023
	Family Coriobacteriaceae	IVW	15	0.377	0.190	1.46 (1.00-2.12)	0.048
	Order Coriobacteriales	IVW	15	0.377	0.190	1.46 (1.00-2.12)	0.048
	Class Coriobacteriia	IVW	15	0.377	0.190	1.46 (1.00-2.12)	0.048

IVW: Inverse-variance weighted; OR: Odds ratio; Nsnp: Number of Single nucleotide polymorphism; SE: Standard error.

Table 2 The heterogeneity results from the Cochran’s Q test, Egger-intercept analysis and PRESSO-analysis

Outcome	Exposure	IVW-Q	Q-P value	Egger-Q	Q-P value	Egger-intercept	SE	P value
Biliary tract cancer
	Genus Eubacterium hallii group	7.393	0.687	4.848	0.847	0.100	0.062	0.145
	Genus Candidatus Soleaferrea	9.726	0.284	5.012	0.658	0.795	0.366	0.066
	Genus Dorea	0.971	0.986	0.962	0.965	-0.010	0.107	0.928
	Genus Flavonifractor	4.673	0.322	2.396	0.494	-0.576	0.381	0.228
	Genus Lachnospiraceae FCS020 group	10.554	0.393	10.46	0.313	-0.016	0.060	0.791
	Genus Lachnospiraceae ND3007 group	3.375	0.184	1.100	0.294	1.473	1.024	0.386
	Order Victivallales	3.460	0.629	3.425	0.489	-0.034	0.182	0.859
	Class Lentisphaeria	3.460	0.629	3.425	0.489	-0.034	0.182	0.859
Hepatocellular carcinoma
	Genus Desulfovibrio	7.263	0.508	6.627	0.468	0.038	0.048	0.451
	Genus Oscillibacter	3.114	0.926	2.956	0.888	0.024	0.062	0.703
	Family Coriobacteriaceae	16.794	0.267	16.76	0.210	0.007	0.051	0.881
	Order Coriobacteriales	16.794	0.267	16.76	0.210	0.007	0.051	0.881
	Class Coriobacteriia	16.794	0.267	16.76	0.210	0.007	0.051	0.881

IVW: Inverse-variance weighted; OR: Odds ratio; SE: Standard error.