Association between gut microbiota and hepatocellular carcinoma and biliary tract cancer: A mendelian randomization study

doi:10.12998/wjcc.v12.i18.3497

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Jun 26, 2024 (publication date) through Jun 29, 2024

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Clin Cases. Jun 26, 2024; 12(18): 3497-3504
Published online Jun 26, 2024. doi: 10.12998/wjcc.v12.i18.3497

Association between gut microbiota and hepatocellular carcinoma and biliary tract cancer: A mendelian randomization study

Ye Zhang, Fa-Ji Yang, Qi-Rong Jiang, Heng-Jun Gao, Xie Song, Hua-Qiang Zhu, Xu Zhou, Jun Lu

Ye Zhang, Fa-Ji Yang, Qi-Rong Jiang, Heng-Jun Gao, Xie Song, Hua-Qiang Zhu, Xu Zhou, Jun Lu, Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250013, Shandong Province, China

Co-first authors: Ye Zhang and Fa-Ji Yang.

Author contributions: Lu J designed experiments; Jiang QR, Gao HJ, Song X, Zhu HQ and Zhou X collected and analyzed the data; Zhang Y wrote the manuscript; Yang FJ and Lu J made critical revisions to the article. All authors have read and approved the final manuscript.

Supported by Natural Science Foundation of China, No. 82200706.

Conflict-of-interest statement: The authors declare no potential conflicts of interests.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jun Lu, MD, PhD, Chief Physician, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jingshi Road, Jinan 250013, Shandong Province, China. lujunsd@126.com

Received: February 25, 2024
Revised: April 9, 2024
Accepted: April 23, 2024
Published online: June 26, 2024
Processing time: 114 Days and 7.2 Hours

Core Tip

Core Tip: We apply the largest intestinal gut microbiota gene database to human disease genetic data, elucidating correlations between gut microbiota and diseases. This aids our understanding of how these bacteria influence or protect against diseases, thereby providing crucial insights into their role in such processes.