Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery

Table 1 Baseline characteristics of patients

Variable	Treatment group (n = 40)	Control group (n = 40)	P value
Age (yr)	58.3 ± 9.2	57.6 ± 8.7	0.68
Sex (male/female)	28/12	26/14	0.67
Tumor stage (I/II/III)	10/18/12	12/16/12	0.81
Surgical approach (open/thoracoscopic)	22/18	24/16	0.69
RDQ score	25.4 ± 9.8	24.8 ± 10.2	0.76

RDQ: Reflux disease questionnaire.

Table 2 Changes in the reflux disease questionnaire score over time

Time	Treatment group (n = 40)	Control group (n = 40)	P value
Baseline	25.4 ± 9.8	24.8 ± 10.2	0.76
6 months	18.2 ± 8.6a	21.6 ± 9.4a	< 0.05
12 months	14.6 ± 7.8a	18.4 ± 8.2a	< 0.05
18 months	12.4 ± 7.2a	16.2 ± 7.6a	< 0.05
24 months	10.2 ± 6.4a	14.8 ± 7.4a	< 0.05

^aP < 0.05, compared with baseline within each group.

Table 3 Changes in the esophageal manometry parameters from baseline to the end of the follow-up period

Variable	Treatment group (n = 40)	Control group (n = 40)	P value
LESP (mmHg)	Baseline: 11.2 ± 3.4	Baseline: 10.8 ± 3.6	< 0.01
	End: 15.6 ± 4.2a	End: 12.4 ± 3.8a
PA (mmHg)	Baseline: 38.6 ± 11.2 End: 52.4 ± 12.6a	Baseline: 37.4 ± 10.8 End: 41.2 ± 11.4a	< 0.01
PV (cm/s)	Baseline: 2.8 ± 0.9 End: 3.6 ± 1.1a	Baseline: 2.7 ± 0.8 End: 2.9 ± 0.9a	< 0.01

^aP < 0.05, compared with baseline within each group.

LESP: Lower esophageal sphincter pressure; PA: Peristaltic amplitude; PV: Peristaltic velocity.

Table 4 Changes in the gastric emptying function from baseline to the end of the follow-up period

Variable	Treatment group (n = 40)	Control group (n = 40)	P value
GEHT (min)	Baseline: 76.4 ± 18.6	Baseline: 75.6 ± 19.2	< 0.05
	End: 58.2 ± 15.4a	End: 68.4 ± 16.8a

^aP < 0.05, compared with baseline within each group.

GEHT: Gastric emptying half-life.

Table 5 Changes in the Short Form-36 score over time

Time	Treatment group (n = 40)	Control group (n = 40)	P value (physical/mental)
Physical domain	Baseline: 72.4 ± 15.6	Baseline: 71.6 ± 16.2	< 0.05
	End: 82.6 ± 14.2a	End: 76.4 ± 15.8a
Mental domain	Baseline: 68.2 ± 13.4	Baseline: 67.4 ± 14.2	< 0.05
	End: 78.4 ± 12.6a	End: 72.2 ± 13.8a

^aP < 0.05, compared with baseline within each group.