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©The Author(s) 2023.
World J Clin Cases. Feb 26, 2023; 11(6): 1393-1402
Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1393
Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1393
Table 1 Dynamic changes of biochemical indexes of liver function in patients
Date | ALT, U/L | AST, U/L | TBIL, μmol/L | DBIL, μmol/L | IBIL, μmol/L | GGT, U/L | ALP, U/L | TBA, U/L |
Ref: 0-40 | Ref: 0-34 | Ref: 5.1-19.0 | Ref: 1.7-6.8 | Ref: 1.7-13.2 | Ref: 10-60 | Ref: 45-120 | Ref: 0-50 | |
2021-09-06 (Pre-operative) | 33.0 | 28.0 | 135.1↑ | 84.1↑ | 51.0↑ | 77.0↑ | 105.0 | 208.0↑ |
2021-09-10 (Post-operative) | 311↑ | 545↑ | 167.6↑ | 106.9↑ | 60.7↑ | 48.0 | 126.0↑ | 120.8↑ |
2021-09-22 | 39.0 | 23.0 | 187.1↑ | 109.4↑ | 77.7↑ | 32.0 | 78.0 | 53.0↑ |
2021-09-28 (Before discharge) | 47.0↑ | 32.0 | 286.2↑ | 166.2↑ | 120.0↑ | 34.0 | 97.0 | 80.9↑ |
2021-10-23 (On readmission) | 43.0↑ | 32.0 | 593.3↑ | 285.9↑ | 307.4↑ | 36.0 | 109.0 | 131.4↑ |
2021-10-30 (After drug treatment) | 30.0 | 27.0 | 602.2↑ | 283.2↑ | 319.0↑ | 23.0 | 97.0 | 213.6↑ |
2021-11-14 (After plasma exchange) | 22.0 | 33.0 | 230.6↑ | 141.1↑ | 89.5↑ | 28.0 | 76.0 | 151.9↑ |
2021-11-17 (Before discharge) | 29.0 | 44.0↑ | 336.7↑ | 193.5↑ | 143.2↑ | 34.0 | 88.0 | 183.0↑ |
Table 2 Results of whole-exon genetic testing for the genetic disorders
Gene | Chromosomal position | Basic variation information | Zygote type | Inheritance patterns |
UGT1A1 | chr2:234669144 | NM_000463.3:c.211G>A (p.Gly71Arg) | Hom | AR |
chr2:234681059 | NM_000463.3:c.1456T>G (p.Tyr486Asp) | Het | AR | |
ABCB11 | chr2:169787353 | NM_003742.4:c.3233T>C (p.Ile1078Thr) | Het | AR |
chr2:169869837 | NM_003742.4:c.334A>G (p.Ile112Val) | Het | AR |
- Citation: Jiang JL, Liu X, Pan ZQ, Jiang XL, Shi JH, Chen Y, Yi Y, Zhong WW, Liu KY, He YH. Postoperative jaundice related to UGT1A1 and ABCB11 gene mutations: A case report and literature review. World J Clin Cases 2023; 11(6): 1393-1402
- URL: https://www.wjgnet.com/2307-8960/full/v11/i6/1393.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i6.1393