Jiang JL, Liu X, Pan ZQ, Jiang XL, Shi JH, Chen Y, Yi Y, Zhong WW, Liu KY, He YH. Postoperative jaundice related to UGT1A1 and ABCB11 gene mutations: A case report and literature review. World J Clin Cases 2023; 11(6): 1393-1402 [PMID: 36926131 DOI: 10.12998/wjcc.v11.i6.1393]
Corresponding Author of This Article
Yi-Huai He, MD, Director, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 26, 2023; 11(6): 1393-1402 Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1393
Postoperative jaundice related to UGT1A1 and ABCB11 gene mutations: A case report and literature review
Jin-Lian Jiang, Xia Liu, Zhong-Qin Pan, Xiao-Ling Jiang, Jun-Hua Shi, Ya Chen, Yu Yi, Wei-Wei Zhong, Kang-Yan Liu, Yi-Huai He
Jin-Lian Jiang, Xia Liu, Xiao-Ling Jiang, Ya Chen, Yu Yi, Kang-Yan Liu, Yi-Huai He, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Zhong-Qin Pan, Department of Infectious Diseases, People's Hospital Qiandongnan Miao and Dong Autonomous Prefecture, Kaili 556000, Guizhou Province, China
Jun-Hua Shi, Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Wei-Wei Zhong, Department of Gastroenterology, First People’s Hospital of Jinmen, Jinmen 448000, Hubei Province, China
Author contributions: Jiang JL and Liu X contributed equally to this work; Jiang JL, Liu X, Jiang XL, and Yi Y collected medical history; Chen Y and Zhong WW summarized and analyzed the medical history data; He YH and Jiang JL conceived and designed the content of the article; Jiang JL and Liu X wrote the initial paper; He YH, Liu KY, Shi JH, and Pan ZQ revised the paper; He YH had primary responsibility for final content; All authors read and approved the final manuscript.
Supported byThe Science and Technology Planning Projects of Guizhou Province and Zunyi City, No. QKHJC-ZK[2022]YB642, No. ZSKH·HZ(2022)344, No. gzwjkj2021-071, ZMC·YZ[2018]38, No. ZSKH·HZ[2021]58, and No. ZSKH·HZ[2021]60; The General Project of Hubei Province and Jingmen City, No. 2021YFYB074.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Huai He, MD, Director, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Received: November 8, 2022 Peer-review started: November 8, 2022 First decision: November 24, 2022 Revised: December 7, 2022 Accepted: February 2, 2023 Article in press: February 2, 2023 Published online: February 26, 2023 Processing time: 108 Days and 5.9 Hours
Core Tip
Core Tip: We presented a case of multiple intrahepatic bile duct stones, cholestasis, and progressive jaundice after surgical treatment, which was diagnosed upon the finding of adenosine triphosphate-binding cassette subfamily B member 11 (ABCB11) and uridine 5’-diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene mutation from the genetic study. Since the patient refused to undergo liver transplantation, his postoperative aggravating jaundice was medically managed, but he soon died due to liver failure. The UGT1A1 gene is related to the glucuronidation of indirect bilirubin. Its mutation leads to increased indirect bilirubin, while the ABCB11 gene is involved in bile transport, and its mutation may lead to disturbance of bile acid transport, changes in bile composition, cholestasis, and the formation of intrahepatic bile duct stones. Surgical treatment in such patients may induce exacerbation of cholestasis, and liver transplantation should be the preferred treatment if medical management fails.
