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©The Author(s) 2023.
World J Clin Cases. Feb 26, 2023; 11(6): 1318-1329
Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1318
Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1318
Table 1 The primary biochemical, hormonal, and ultrasonic criteria at the initial visit, 3 mo and 6 mo later, with their statistical comparison
Parameter | First visit value, n = 54 | 2nd visit at 3 mo, n = 54 | 3rd visit at 6 mo, n = 54 | P value |
Cholesterol in mg/dL | 384.19 ± 13.64 | 337.25 ± 18.40 | 276.82 ± 12.69 | < 0.030 |
HDL in mg/dL | 35.70 ± 3.78 | 48.70 ± 4.31 | 62.52 ± 4.09 | < 0.001 |
LDL in mg/dL | 203.22 ± 8.74 | 167.41 ± 12.26 | 132.33 ± 12.62 | < 0.040 |
Fasting blood sugar in mg/dL | 92.22 ± 1.80 | 90.93 ± 2.42 | 92.07 ± 2.43 | 0.071 |
HOMA-IR | 2.26 ± 0.07 | 2.02 ± 0.10 | 1.74 ± 0.07 | < 0.001 |
SHBG in nmol/L | 29.52 ± 7.11 | 58.29 ± 8.25 | 81.74 ± 7.49 | < 0.001 |
Testosterone in ng/dL | 108.30 ± 8.29 | 79.74 ± 9.45 | 51.56 ± 7.96 | < 0.010 |
LH / FSH_Ratio | 2.62 ± 0.12 | 2.23 ± 0.15 | 1.76 ± 0.13 | < 0.001 |
PI | 1.41 ± 0.08 | 1.13 ± 0.07 | 0.89 ± 0.07 | < 0.034 |
RI | 0.89 ± 0.04 | 0.77 ± 0.05 | 0.62 ± 0.04 | < 0.040 |
CIMT in mm | 0.92 ± 0.03 | 0.79 ± 0.03 | 0.66 ± 0.03 | < 0.001 |
AUC- ICA Doppler | 56.44 ± 4.49 | 42.11 ± 4.06 | 31.29 ± 3.93 | < 0.001 |
Table 2 Correlations of area under the curve - internal carotid artery Doppler vs study variables over 6 mo with metformin therapy for women recruited to this study
AUC- ICA vs parameter | Coefficient of correlation | P value |
Cholesterol in mg/dL | 0.81 | 0.03 |
HDL in mg/dL | -0.92 | 0.002 |
LDL in mg/dL | 0.88 | 0.04 |
HOMA_IR | 0.98 | 0.0001 |
SHBG in nmole/L | -0.90 | 0.01 |
Testosterone in ng/dL | 0.86 | 0.001 |
LH/ FSH_ratio | 0.91 | 0.007 |
PI | 0.87 | 0.002 |
RI | 0.8 | 0.009 |
CIMT in mm | 0.95 | 0.0001 |
24 wk of metformin therapy | -0.99 | 0.001 |
Table 3 Best subset regression between homeostasis model assessment for insulin resistance as the main dependent variable vs carotid artery intima-media thickness, pulsatility indices, resistance indices and area under the curve of the carotid artery Doppler with calculation of associated Mallow’s coefficient
Variable | (Cp) Mallow’s coefficient |
AUC-ICA | 49.6 |
CIMT | 155.5 |
PI | 326.8 |
R1 | 637.0 |
- Citation: Akram W, Nori W, Abdul Ghani Zghair M. Metformin effect on internal carotid artery blood flow assessed by area under the curve of carotid artery Doppler in women with polycystic ovarian syndrome. World J Clin Cases 2023; 11(6): 1318-1329
- URL: https://www.wjgnet.com/2307-8960/full/v11/i6/1318.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i6.1318