Effect of liver transplantation with primary hyperoxaluria type 1: Five case reports and review of literature

Table 1 Preoperative laboratory examination

	Case 1	Case 2	Case 3	Case 4	Case 5
eGFR in mL/min/1.73 m2	55.1	5.8	5.7	71.0	6.4
HGB in g/L	139	85	71	127	64
K+ in mmol/L	4.4	4.8	6.2	4.5	4.2
Na+ in mmol/L	140.1	142.2	140.9	139.6	142.2
Ca2+ in mmol/L	2.4	2.2	2.4	2.5	2.4
Urine OA/Cr in µg/mg Cr	824.83	Anuria	596.01	609.21	962.65
Serum OA as LT/KT in µmol/L	-	-/452	134/142.5	-	233.6/-

eGFR: Estimated glomerular filtration rate; HGB: Hemoglobin; KT: Kidney transplantation; LT: Liver transplantation; OA: Oxalic acid; OA/Cr: Oxalic acid/creatinine.

Table 2 Operative and postoperative clinical data

	Case 1	Case 2	Case 3	Case 4	Case 5
Tx	Pre-LT	SLKT	SLKT	Pre-LT	SLKT
LT donor	Mother	DCD	Mother	Mother	Mother
Liver segments	Left lobe graft	Left lobe graft	Right lobe graft	Left lobe graft	Left lateral section
Interval between LT and KT in mo	-	2.3	4.3	-	9.8
Serum OA level before Tx as LT/KT in μmol/L	-	-/452.0	134.0/142.5	-	233.6/-
Time in ICU as LT/KT in d	4	5/-	6/11	3	18/5
Dialysis early postoperative period as LT/KT	-	CVVHDF 5 d, HD 5.5 mo/HD 2.5 mo	HD 4.0 mo/-	-	HD/HD
Follow-up time in mo	35.9	40.1	26.3	13.1	12.8
Early postoperative complications	-	Biliary leakage	Fungal infections, hepatic artery occlusion, biliary leakage	-	Pneumonia, rotavirus diarrhea
Complications during the follow-up	CMV infection, mycoplasma infection	-	CMV infection	Hilar bile duct stricture, intrahepatic biliary ducts dilatation, obstructive jaundice	-
Liver outcome	Functional	Functional	Functional	Functional	Functional
Kidney outcome	-	Functional	Functional	-	Functional
Patient survival	Alive	Alive	Alive	Alive	Alive
Acute rejection	-	-	-	-	-
Current eGFR in mL/min/1.73m2	127.4	20.5	52.0	157.0	178.7

-: Did not happen or the data was not recorded. CMV: Cytomegalovirus; CVVHDF: Continuous veno-venous hemodiafiltration; DCD: Donation after cardiac death; eGFR: Estimated glomerular filtration rate; HD: Hemodialysis; ICU: Intensive care unit; KT: Kidney transplantation; LT: Liver transplantation; OA: Oxalic acid; Pre-LT: Preemptive liver transplantation; SLKT: Estimated glomerular filtration rate; Tx: Transplantation.