Asian variant intravascular large B-cell lymphoma with highly suspected central nervous system involvement: A case report

Table 1 Patient characteristics and laboratory findings at diagnosis

Sex/age (yr)	ECOG	Disease involvement sites	Ann Arbor stage	IPI	Cell of origin	WBC (103/μL)	Hb (g/dL)	Plt (103/μL)	LDH (IU/L)	CRP (mg/dL)	Ferritin (ng/mL)
F/67	4	Right ethmoid sinus, liver, spleen, bilateral adrenal glands	IV	5	Non-GCB	5.35	8.5	77	891	5.26	835

CRP: C-reactive protein; ECOG: Eastern Cooperative Oncology Group performance status; GCB: Germinal center B-cell; Hb: Hemoglobin; IPI: International Prognostic Index; LDH: Lactate dehydrogenase; Plt: Platelet; WBC: White blood cell.

Table 2 Variants found in next-generation sequencing

Tier 1 variants				Tier 2 variants				Tier 3 variants
Gene	DNA	Protein	VAF	Gene	DNA	Protein	VAF	Gene	DNA	Protein	VAF
MYD88	c.755T>C	p.Leu252Pro	54.8%	PIM1	c.237G>C	p.Glu79Asp	30.77%	NOTCH1	c.6283C>T	p.Arg2095Cys	37.7%
								ETV6	c.1123G>A	p.Gly375Arg	14.4%
TET2	c.3280A>T	p.Lys1094Ter	16.0%	BTG2	c.97C>T	p.Gln33Ter	19.6%	HIST1H1E	c.367G>A	p.Ala123Thr	15.6%
								TBL1XR1	c.848G>A	p.Ser283Asn	16.5%

DNA: Deoxyribonucleic acid; VAF: Variant allele frequency.