Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2023; 11(33): 8058-8064
Published online Nov 26, 2023. doi: 10.12998/wjcc.v11.i33.8058
Asian variant intravascular large B-cell lymphoma with highly suspected central nervous system involvement: A case report
Yong-Pyo Lee, Seung-Myoung Son, Jihyun Kwon
Yong-Pyo Lee, Jihyun Kwon, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, South Korea
Seung-Myoung Son, Department of Pathology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju 28644, South Korea
Author contributions: Lee YP and Son SM contributed to manuscript writing and editing and to data collection; Lee YP and Kwon JH contributed to data analysis; Kwon JH contributed to conceptualization and supervision; All authors have read and approved the final manuscript.
Informed consent statement: The institutional review board of Chungbuk National University Hospital approved this study (approval number. CBNUH 2023-04-024), and informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jihyun Kwon, MD, PhD, Associate Professor, Doctor, Department of Internal Medicine, Chungbuk National University Hospital, 776, 1Sunhwan-ro, Seowon-gu, Cheongju 28644, South Korea. marioncrepe@gmail.com
Received: September 3, 2023
Peer-review started: September 3, 2023
First decision: October 24, 2023
Revised: November 1, 2023
Accepted: November 10, 2023
Article in press: November 10, 2023
Published online: November 26, 2023
Processing time: 81 Days and 21.6 Hours
Core Tip

Core Tip: Intravascular large B-cell lymphoma (IVLBCL) is a rare but clinically aggressive lymphoproliferative disease. Given its aggressive nature, immediate diagnosis of IVLBCL and timely treatment are critical for better clinical outcomes. As central nervous system (CNS) involvement adversely affects prognosis if IVLBCL, active CNS examination is required at diagnosis. In addition, along with conventional pathology, targeted sequencing contributes to diagnosis and provides a basis for use of targeted agents. Here, we report a case of Asian variant IVLBCL with highly suspected CNS involvement. We first describe the clinical course of disease and then discuss the genetic aberrations found in the patient.