Emerging trends and hotspots of Nuclear factor erythroid 2-related factor 2 in nervous system diseases

Table 1 Top 5 research areas/journals/funding agencies according to the number of documents

Field		Record count (%)
Research areas	Neurosciences	585, 31.05
	Biochemistry Molecular Biology	437, 23.20
	Pharmacology Pharmacy	381, 20.22
	Cell Biology	223, 11.84
	Medicine Research Experimental	152, 8.07
Journals	Oxidative Medicine and Cellular Longevity	63, 3.34
	Antioxidants	43, 2.28
	Frontiers in Pharmacology	43, 2.28
	Molecular Neurobiology	37, 1.96
	International Journal of Molecular Sciences	35, 1.86
Funding agencies	National Natural Science Foundation Of China	517, 27.44
	United States Department Of Health Human Services	220, 11.68
	National Institutes Of Health United States	219, 11.62
	National Institute Of Neurological Disorders Stroke Ninds	81, 4.30
	European Commission	61, 3.24

Table 2 Top 5 countries and institutions in terms of the number of documents

Field		Record count (%)	Centrality
Countries	China	972, 51.59	0.14
	United States	384, 20.38	0.78
	South Korea	106, 5.63	0.11
	Italy	87, 4.62	0.12
	India	71, 3.77	0.06
Affiliations	Nanjing University	53, 2.81	0.18
	Fourth Military Medical University	41, 2.18	0.06
	Nanjing Medical University	32, 1.70	0.04
	China Medical University	31, 1.65	0.06
	Chongqing Medical University	29, 1.54	0.01

Table 3 Frequency of keyword co-occurrence (top 25 counts, 2010–2022)

Keywords	Count	Centrality
Oxidative stress	1140	0.01
NRF2	473	0.00
Activation	400	001
Expression	327	0 01
Brain	271	0 03
Stroke	265	0.02
Nf kappa B	206	0.02
Alzheimer’s disease	195	0.02
Pathway	192	0.02
Apoptosis	187	0.02
Protect	186	0.02
Injury	186	003
Inflammation	169	0.03
Mechanism	168	0.02
Cell	152	0.01
Traumatic brain injury	147	0.03
Damage	143	0.02
Model	141	0.03
Heme oxygenase 1	132	0.03
Brain injury	132	0.03
Parkinson’s disease	129	10.01
Antioxidant	129	0.00
Signaling pathway	124	0.01
Mouse model	119	0.04
Rat	116	0.03

NRF2: Nuclear factor erythroid 2-related factor 2.