Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2023; 11(32): 7833-7851
Published online Nov 16, 2023. doi: 10.12998/wjcc.v11.i32.7833
Published online Nov 16, 2023. doi: 10.12998/wjcc.v11.i32.7833
Emerging trends and hotspots of Nuclear factor erythroid 2-related factor 2 in nervous system diseases
Xue-Qin Chang, Ling Xu, Yi-Xuan Zuo, Yi-Guo Liu, Jia Li, Hai-Tao Chi, Department of Neurology, Xinhua Hospital Affiliated with Dalian University, Dalian 116011, Liaoning Province, China
Author contributions: Chang XQ designed and performed the research; Zuo YX, Liu YG, and Li J conducted the statistical analysis.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 checklist and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Tao Chi, Doctor, Chief Doctor, Department of Neurology, Xinhua Hospital Affiliated with Dalian University, No. 156 Wansui Street, Shahekou District, Dalian 116011, Liaoning Province, China. 723290269@qq.com
Received: August 24, 2023
Peer-review started: August 24, 2023
First decision: September 28, 2023
Revised: October 4, 2023
Accepted: October 30, 2023
Article in press: October 30, 2023
Published online: November 16, 2023
Peer-review started: August 24, 2023
First decision: September 28, 2023
Revised: October 4, 2023
Accepted: October 30, 2023
Article in press: October 30, 2023
Published online: November 16, 2023
Core Tip
Core Tip: In this paper, the research progress of nuclear factor erythroid 2-related factor 2 (NRF2) expression, activation, mechanism of action, and related targets in nervous system diseases is explored based on related articles published in the past decade. Oxidative stress plays a crucial role in their pathological process, and there have been many studies on the treatment of nervous system diseases based on oxidative stress targets. As a key factor against oxidative stress, NRF2 plays an important role in the nervous system. Through computational analysis of the literature, we will present the research hotspots and possible future research directions of NRF2 in the nervous system.