Exploring the pharmacological mechanism of Wuzhuyu decoction on hepatocellular carcinoma using network pharmacology

Table 1 Top 10 Gene Ontology enrichment items

ID	Description	P value	Adjust P value	Gene number	GO items
GO:0032496	Response to lipopolysaccharide	2.70E-29	1.11E-25	37	BP
GO:0042493	Response to drug	5.99E-29	1.23E-25	38	BP
GO:0002237	Response to molecule of bacterial origin	2.40E-28	3.27E-25	37	BP
GO:0062197	Cellular response to chemical stress	4.08E-27	4.17E-24	36	BP
GO:0072593	Reactive oxygen species metabolic process	1.25E-26	1.02E-23	33	BP
GO:0010038	Response to metal ion	1.37E-24	9.36E-22	34	BP
GO:0070482	Response to oxygen levels	2.05E-24	1.20E-21	35	BP
GO:0001666	Response to hypoxia	1.28E-23	6.56E-21	33	BP
GO:0000302	Response to reactive oxygen species	1.99E-23	9.03E-21	28	BP
GO:0034599	Cellular response to oxidative stress	2.21E-23	9.04E-21	31	BP
GO:0045121	Membrane raft	1.49E-20	2.36E-18	29	CC
GO:0098857	Membrane microdomain	1.49E-20	2.36E-18	29	CC
GO:0044853	Plasma membrane raft	6.06E-09	6.38E-07	11	CC
GO:1902911	Protein kinase complex	4.05E-08	3.20E-06	10	CC
GO:0000307	Cyclin-dependent protein kinase holoenzyme complex	1.18E-07	6.68E-06	7	CC
GO:1902554	Serine/threonine protein kinase complex	1.27E-07	6.68E-06	9	CC
GO:0090575	RNA polymerase II transcription regulator complex	4.95E-07	2.24E-05	11	CC
GO:0005901	Caveola	7.06E-07	2.79E-05	8	CC
GO:0005667	Transcription regulator complex	5.82E-06	0.000192173	15	CC
GO:0031968	Organelle outer membrane	6.14E-06	0.000192173	11	CC
GO:0140297	DNA-binding transcription factor binding	5.06E-17	9.61E-15	28	MF
GO:0004879	Nuclear receptor activity	5.46E-17	9.61E-15	14	MF
GO:0098531	Ligand-activated transcription factor activity	5.46E-17	9.61E-15	14	MF
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	2.32E-15	3.06E-13	23	MF
GO:0003707	Steroid hormone receptor activity	1.78E-12	1.88E-10	9	MF
GO:0044389	Ubiquitin-like protein ligase binding	2.35E-10	2.07E-08	19	MF
GO:0001223	Transcription coactivator binding	4.22E-09	2.70E-07	7	MF
GO:0031625	Ubiquitin protein ligase binding	4.53E-09	2.70E-07	17	MF
GO:0017171	Serine hydrolase activity	4.71E-09	2.70E-07	14	MF
GO:0051879	Hsp90 protein binding	5.12E-09	2.70E-07	8	MF

BP: Biological process; CC: Cellular component; GO: Gene Ontology; Hsp90: Heat shock protein 90; MF: Molecular function.