Ouyang JY, Lin WJ, Dong JM, Yang Y, Yang HK, Zhou ZL, Wang RQ. Exploring the pharmacological mechanism of Wuzhuyu decoction on hepatocellular carcinoma using network pharmacology. World J Clin Cases 2023; 11(27): 6327-6343 [PMID: 37900230 DOI: 10.12998/wjcc.v11.i27.6327]
Corresponding Author of This Article
Rui-Qi Wang, PhD, Lecturer, Department of Pharmacy, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Corning Road, Zhuhai 519000, Guangdong Province, China. wangrq2020@ext.jnu.edu.cn
Research Domain of This Article
Pharmacology & Pharmacy
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 26, 2023; 11(27): 6327-6343 Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6327
Exploring the pharmacological mechanism of Wuzhuyu decoction on hepatocellular carcinoma using network pharmacology
Jia-Ying Ouyang, Wei-Jie Lin, Jia-Mei Dong, Yang Yang, Hai-Kui Yang, Zhi-Ling Zhou, Rui-Qi Wang
Jia-Ying Ouyang, Wei-Jie Lin, Jia-Mei Dong, Yang Yang, Hai-Kui Yang, Zhi-Ling Zhou, Rui-Qi Wang, Department of Pharmacy, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, Guangdong Province, China
Author contributions: Ouyang JY, Lin WJ, and Dong JM primarily conducted this study; Yang Y and Yang HK provided technical support in network pharmacology and molecular docking; Zhou ZL and Wang RQ provided the concept, ideas support, and manuscript revision; All authors agree to be accountable for all aspects of work ensuring integrity and accuracy.
Supported bythe Xiangshan Talented Scientific Research Project of Zhuhai People’s Hospital, No. 2021XSYC-02; and Research Start Project of Zhuhai People’s Hospital, No. 2020ycqd001.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The names of the repository/repositories and search keywords(s) can be found in the article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui-Qi Wang, PhD, Lecturer, Department of Pharmacy, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Corning Road, Zhuhai 519000, Guangdong Province, China. wangrq2020@ext.jnu.edu.cn
Received: April 21, 2023 Peer-review started: April 21, 2023 First decision: May 19, 2023 Revised: June 24, 2023 Accepted: July 28, 2023 Article in press: July 28, 2023 Published online: September 26, 2023 Processing time: 152 Days and 9.3 Hours
Core Tip
Core Tip: Six main active components (quercetin, kaempferol, ginsenoside Rh2, rutaecarpine, β-carotene, and β-sitosterol) and ten core genes (tumor necrosis factor, interleukin-6, AKT1, TP53, caspase-3, mitogen-activated protein kinase 1, epidermal growth factor receptor, MYC, mitogen-activated protein kinase 8, and JUN) were obtained from Wuzhuyu decoction. In addition, 179 pathways were obtained from Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, which indicated that Wuzhuyu decoction is a multicomponent, multitarget, and multipathway treatment for hepatocellular carcinoma. The active components of Wuzhuyu decoction may participate in these pathways via the top 10 hub genes, which achieves the therapeutic effect on hepatocellular carcinoma.
