Risk factors for stroke recurrence in young patients with first-ever ischemic stroke: A meta-analysis

Table 1 Basic Information of selected literature

Number	Ref.	Number of cases	Number of controls	Publication of journals
1	Yang et al[11], 2016	64	171	Neuroscience
2	Xu et al[12], 2021	110	139	BMC Neurology
3	Fan et al[13], 2018	74	358	Medicine
4	Putaala et al[14], 2009	86	550	Neurology
5	Song et al[15], 2017	293	64	International Journal of Neuroscience
6	Subha et al[16], 2015	15	85	Ann Indian Acad Neurol
7	Gupta et al[17], 2022	63	63	Annals of indian Academy
8	Vibo et al[18], 2021	273	164	European Stroke
9	Zhao et al[19], 2017	121	575	World Neurosurgery
10	MacIntosh et al[6], 2021	2192	6101	Journal of the American Heart Association

Table 2 Methodological quality evaluation results of included literature (Unit: Points)

Ref.	Research selection	Intergroup comparability	Result measure	Literature quality
Yang et al[11]	4	2	3	9
Xu et al[12]	4	1	3	8
Fan et al[13]	3	2	3	8
Putaala et al[14]	3	2	3	8
Song et al[15]	4	2	2	8
Subha et al[16]	4	2	2	8
Gupta et al[17]	3	2	3	8
Vibo et al[18]	4	2	3	9
Zhao et al[19]	3	2	3	8
MacIntosh et al[6]	3	2	2	7

Table 3 Meta-analysis results of stroke recurrence in young ischemic stroke patients

Risk factor	Number of merged literature	Case group	Control group	I2, %	P value	Metaanalysis model	Merge OR values	95%CI
Male	5	2678	7049	80.80	< 0.001	Random effect model	1.66	(0.98-2.79)
Hypertension	7	2661	7871	59.20	0.023	Random effect model	1.54	(1.05-2.26)
Hyperlipidemia	5	2430	7157	0.00	0.764	Fixed effect model	1.12	(1.00-1.25)
Type 2 diabetes	6	2551	7732	42.70	0.12	Fixed effect model	1.01	(0.64-1.59)
Smoking	5	2430	7157	71.10	0.008	Random effect model	1.21	(0.83-1.76)
Drinking	3	152	506	41.10	0.183	Fixed effect model	1.28	(0.82-2.53)