Rare ROS1-CENPW gene in pancreatic acinar cell carcinoma and the effect of crizotinib plus AG chemotherapy: A case report

Table 1 Variation of tumor markers

Date	CEA (ng/mL) normal range: 0-5.00	CA199 (U/mL) normal range: 0-37.00	CA125 (U/mL) normal range: 0-35.00	AFP (ng/mL) normal range: 0-20.00
3.30	58.81	233.70	4.45	0.97
5.8	48.69	133.80	9.24	3.18
5.24	38.16	245.10	5.15	1.01

AFP: Alpha-fetoprotein; CA: Carbohydrate antigen; CA125: Cancer antigen 125; CEA: Carcinoembryonic antigen.

Table 2 Somatic mutation results

Gene	Transcript	Nucleobase alternation	Amino acid alternation	Functional domain	Mutation frequency
KRAS	NM_033360.2	c.34G>C	p.G12R	EX2	52.7%
PIK3R2	NM_005027.2	c.443C>T	p.P148L	EX4	18.0%
TP53	NM_000546.5	c.797G>T	p.G266V	EX8	15.1%
TGFBR2	NM_001024847.2	c.1528_1532delGAAAG	p.E510Hfs*29	EX7	15.0%
CDKN2A	NM_000077.4	c.35C>A	p.S12*	EX1	13.9%

Table 3 Gene copy coefficient results

Gene	Transcript	Mutation type	Functional domain	Copy coefficient
KRAS	NM_033360.2	Amplification	All exon	1.7

Table 4 Gene fusion results

Gene	Transcript	Mutation type	Functional domain	Mutation frequency
ROS1-CENPW (intergenic)	NM_002944.2; NM_001012507.2	Fusion	EX41:intergenic	21.6%