Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5823-5829
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5823
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5823
Rare ROS1-CENPW gene in pancreatic acinar cell carcinoma and the effect of crizotinib plus AG chemotherapy: A case report
Tao Wang, Graduate School, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Yi-Yu Shen, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314051, Zhejiang Province, China
Author contributions: Wang T analyzed the data and wrote the manuscript; Shen YY conducted data collection, analysis, and chart production; All authors have read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Yu Shen, MCh, Chief Physician, Doctor, Surgeon, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Jiaxing University, No. 1518 Huancheng North Road, Jiaxing 314051, Zhejiang Province, China. syjdr@163.com
Received: June 13, 2023
Peer-review started: June 13, 2023
First decision: July 7, 2023
Revised: July 16, 2023
Accepted: July 28, 2023
Article in press: July 28, 2023
Published online: August 26, 2023
Peer-review started: June 13, 2023
First decision: July 7, 2023
Revised: July 16, 2023
Accepted: July 28, 2023
Article in press: July 28, 2023
Published online: August 26, 2023
Core Tip
Core Tip:ROS1-CENPW is a novel fusion gene locus in pancreatic acinar cell carcinoma that has not been previously reported. We detected this rare fusion gene in a 77-year-old female patient with pancreatic acinar cell carcinoma. We adopted the treatment regimen of crizotinib combined with AG chemotherapy (gemcitabine 1000 mg/m2 plus albumin paclitaxel 125 mg/m2). A good therapeutic effect was achieved.