Neonatal erythema multiforme associated with a rotavirus infection: A case report

Table 1 Laboratory findings from a neonate with erythematous multiforme associated with rotavirus infection

Test	Results (normal range)
Complete blood cell count
White blood cell (/µL)	7450 (9100-34000)
Neutrophil (%)	32.7 (54.0-62.0)
Lymphocyte (%)	56.5 (25.0-33.0)
Eosinophil (%)	1.6 (1.0-3.0)
Hemoglobin (g/dL)	12.0 (15.0-24.0)
Platelet (/µL)	649000 (150000-400000)
Chemical
Aspartate aminotransferase (IU/L)	32 (22-71)
Alanine aminotransferase (IU/L)	28 (10-40)
BUN (mg/dL)	8.7 (3.0-12.0)
Creatinine (mg/dL)	0.30 (0.03-0.50)
Albumin (g/dL)	3.8 (1.9-4.9)
hs-CRP (mg/dL)	0.06 (0.08-1.58)
Total bilirubin (mg/dL)	2.86 (< 22.01)
Urinalysis
Protein	Negative
White blood cell (/HPF)	0-1
Red blood cell (/HPF)	0-1
Coagulation
Prothrombin time (international normalized ratio)	0.85 (< 1.2)
Activated partial thromboplastin time (s)	27.1 (25.6-33.4)
Antibodies
Toxoplasma IgG/IgM	Negative/Negative
Rubella IgG/IgM	Equivocal/Negative
Herpes Simplex Virus IgG/IgM	Positive/Negative
Cytomegalovirus IgG/M Ab	Positive/Negative
Epstein-Barr virus viral-capsid antigen IgM Ab	Positive/Negative
PCR
Respiratory panel (virus2/bacteria3) (nasopharyngeal swab)	Negative/Negative
Acute diarrhea panel (virus4/bacteria5) (stool)	Rotavirus/Negative
Severe acute respiratory syndrome coronavirus 2 (nasopharyngeal swab)	Negative

¹Hour-specific thresholds for phototherapy in newborns 38 wk gestation with unconjugated hyperbilirubinemia in the absence of neurotoxicity risk factors.

²Adenovirus, Influenza A/B virus, Parainfluenza virus 1/2/3/4, Human rhinovirus, bocavirus 1/2/3/4, Coronavirus 229E/NL63/OC43, Enterovirus, Metapneumovirus, Respiratory syncytial virus A/B.

³Bordetella pertussis, Chlamydophila pneumoniae, Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, and Streptococcus pneumoniae.

⁴Rotavirus, Norovirus GI/II, Astrovirus, Enteric adenovirus, Sapovirus.

⁵Campylobacter spp., Clostridium difficile Toxin B, Salmonella spp., Shigella spp., Enteroinvasive Escherichia coli, Vibrio spp., Yersinia enterocolitica, Aeromonas spp., Clostridium difficile hypervirulent, E. coli O157, Shiga toxin-producing E. coli, Enteropathogenic E. coli, Enterotoxigenic E. coli, Enteroaggregative E. coli.

BUN: Blood urea nitrogen; hs-CRP: High-sensitivity C-reactive protein; HPF: High-power field; IgG: Immunoglobulin G; IgM: Immunoglobulin M; Ab: Antibody; PCR: Polymerase chain reaction.