Efficacy and safety of Huangqi Jianzhong decoction in the treatment of chronic atrophic gastritis: A meta-analysis

Table 1 Descriptions of the studies included in the review

Ref.	Age	Male/Female	Number of cases	Intervention	Duration of intervention	Outcome
Ji et al[14], 2022	C: 52.55 ± 9.57; T: 51.34 ± 10.52	C = 34/26; T = 35/25	C: n = 60; T: n = 60	C: Amoxicillin + Clarithromycin + Rabeprazole; T: Amoxicillin + Clarithromycin + HQJZD + Rabeprazole	8 wk	Total effective rate; PG-I
Liu et al[15], 2022	C: 52.27 ± 13.63; T: 51.94 ± 12.86	C=20/18; T=22/16	C: n = 38; T: n = 38	C: Omeprazole; T: Omeprazole + HQJZD	8 wk	Total effective rate; Stomachache
Zhao et al[16], 2017	C: 45.32 ± 5.61; T: 46.78 ± 5.89	C: 19/17; T: 20/16	C: n = 36; T: n = 36	C: Rabeprazole + Hydrotalcite; T: Rabeprazole + Hydrotalcite + HQJZD	8 wk	Total effective rate; Stomachache; Acid reflux; Adverse reaction; Recurrence rate
Ding et al[17], 2019	C: 50.27 ± 10.12; T: 51.03 ± 9.89	C: 34/21; T: 32/23	C: n = 55; T: n = 55	C: Amoxicillin + Clarithromycin + Omeprazole; T: Amoxicillin + Clarithromycin + HQJZD + Omeprazole	12 wk	Total effective rate; Stomachache; Acid reflux; PG-I
Huang et al[18], 1998	C: 54.3 ± 4.5; T: 53.5 ± 4.7	C: 25/20; T: 26/19	C: n = 45; T: n = 45	C: Amoxicillin + Clarithromycin + Omeprazole + Folate; T: Amoxicillin + Clarithromycin + Omeprazole+ Folate + HQJZD	4 wk	Total effective rate
Yao et al[19], 2020	C: 54.3 ± 4.5; T: 53.5 ± 4.7	C: 25/20; T: 26/19	C: n = 45; T: n = 45	C: Amoxicillin + Clarithromycin + Rabeprazole+ Colloidal bismuth pectin citrate; T: Amoxicillin + Clarithromycin + Rabeprazole+ Colloidal bismuth pectin citrate +HQJZD	2 wk	Total effective rate; Stomachache; Acid reflux; PG-I; Adverse reaction; H. pylori eradication rate
Lu et al[20], 2019	C: 46.8 ± 16.5; T: 47.4 ± 16.7	C: 56/37; T: 58/35	C: n = 93; T: n = 93	C: Weifuchun; T: HQJZD	12 wk	Total effective rate; PG-I
Hong et al[21], 2020	C: 63.53 ± 6.81; T: 65.18 ± 5.37	C: 36/23; T: 33/26	C: n = 59; T: n = 59	C: Weifuchun; T: HQJZD	12 wk	Total effective rate; Stomachache
Xu et al[22], 2016	C: 68.17 ± 10.58; T: 68.26 ± 10.63	C: 22/17; T: 21/18	C: n = 39; T: n = 39	C: Vitacoenzyme; T: HQJZD	8 wk	Total effective rate; Stomachache; Acid reflux; Adverse reaction; Recurrence rate
Yan et al[23], 2012	C: 40 ± 9.6; T: 41 ± 8.3	C: 38/22; T: 40/25	C: n = 60; T: n = 65	C: Weifuchun; T: HQJZD	12 wk	Total effective rate; H. pylori eradication rate
Zhang et al[24], 2017	NS	NS	C: n = 40; T: n = 40	C: Weifuchun; T: HQJZD	8 wk	Total effective rate; Adverse reaction
Fu et al[25], 2013	C: 54.60 ± 5.64; T: 49.60 ± 6.11	C: 38/22; T: 16/14	C: n = 30; T: n = 30	C: Vitacoenzyme; T: HQJZD	8 wk	Total effective rate; Adverse reaction
Xie et al[26], 2018	C: 46.0 ± 2.7; T: 44.5 ± 2.6	C: 19/15; T: 17/17	C: n = 34; T: n = 34	C: Rabeprazole + Hydrotalcite; T: HQJZD	8 wk	Total effective rate; Stomachache; Acid reflux

HQJZD: Huangqi Jianzhong decoction; H. pylori: Helicobacter pylori; PG-1: Pepsinogen I; NS: Not significant; T: Represents the treatment group; C: Represents the control group.