Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5710-5720
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5710
Efficacy and safety of Huangqi Jianzhong decoction in the treatment of chronic atrophic gastritis: A meta-analysis
Xin-Peng Yan, Wen Si, Ming-Sheng Ding, Yuan-Fen Tian, Zhuang Guo
Xin-Peng Yan, Ming-Sheng Ding, Department of Traditional Chinese Medicine, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Wen Si, Department of Endocrinology, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Yuan-Fen Tian, Children’s Rehabilitation and Health Care Department, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Zhuang Guo, Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Author contributions: Yan XP, Guo Z contributed to conceptualization, methodology, project administration, resources, contributed to software, visualization, writing-review & editing; Si W contributed to data curation; Ding MS contributed to formal analysis; Tian YF contributed to investigation; Guo Z contributed to supervision and validation; Yan XP contributed to writing -original draft.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhuang Guo, MD, Attending Doctor, Department of Gastroenterology, Shengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying 257034, Shandong Province, China. guozhuangvx25@163.com
Received: July 10, 2023
Peer-review started: July 10, 2023
First decision: July 18, 2023
Revised: July 22, 2023
Accepted: July 31, 2023
Article in press: July 31, 2023
Published online: August 26, 2023
ARTICLE HIGHLIGHTS
Research background

Chronic atrophic gastritis is a persistent disorder of the digestive system where the gastric mucosa epithelium and glands undergo atrophy, leading to a decrease in their number and thinning of the gastric mucosa. It is worth noting that the prevalence of chronic atrophic gastritis is higher in China compared to the global average, and it is also considered a precancerous condition for gastric cancer.

Research motivation

Currently, Western medicine treatments for chronic atrophic gastritis can only slow down the progression of the disease and are not capable of providing an effective cure. Therefore, we aim to investigate the therapeutic effects of Huangqi Jianzhong Decoction on chronic atrophic gastritis from the perspective of traditional Chinese medicine, aiming to enhance patients’ quality of life.

Research objectives

To assess the therapeutic efficacy of Huangqi Jianzhong Decoction for chronic atrophic gastritis.

Research methods

We conducted a literature review on the treatment of chronic atrophic gastritis with Huangqi Jianzhong Decoction, focusing on publications up until January 2023. The collected literature was analyzed for heterogeneity, and a meta-analysis was performed using Revman 5.4 and the Cochrane Handbook.

Research results

We included a total of 13 articles, comprising 1269 patients. The findings of our analysis revealed that the use of Huangqi Jianzhong Decoction in the treatment of chronic atrophic gastritis led to significant improvements in various aspects. These improvements included an increased clearance rate of Helicobacter pylori, alleviation of symptoms such as stomach pain, and a reduction in the recurrence rate of patients. However, there was no significant change observed in the levels of Pepsin I.

Research conclusions

Huangqi Jianzhong Decoction has a significant therapeutic effect on patients with chronic atrophic gastritis, including improvements in the clearance rate of Helicobacter pylori, reduction of stomachache, alleviation of gastric acid reflux, and decreased disease recurrence rate.

Research perspectives

Traditional Chinese medicine represents a longstanding treatment approach in China. When approaching the treatment of chronic atrophic gastritis from a traditional Chinese medicine perspective, our focus lies not only on symptom relief but also on studying treatment methods that effectively address the condition. By doing so, we aim to improve the overall quality of life for patients, going beyond mere alleviation of the disease process.