Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis

Table 1 Data of the two microarray datasets derived from the Gene Expression Omnibus database

Dataset ID	Tumor	Normal	Total number
GSE116959	57	11	68
GSE118370	6	6	12

Table 2 Data obtained using CytoHubba and CytoNCA

	Gene symbol	Betweenness centrality (≥ 50)	Gene symbol	Degree (≥ 10)
1	CDH1	611.39685	CDH1	34
2	TOP2A	167.13333	TOP2A	16
3	CD19	166.32063	CRABP2	12
4	FCRL2	117.73333	MMP13	12
5	CRABP2	96.13333	MMP12	12
6	MYO6	78.28889	CXCL14	12
7	SFRP4	62.00000	CD19	10
8	ADAM8	62.00000	LTF	10
9	SRGAP1	56.266666	-	-
10	MMP12	51.720634	-	-

ADAM8: ADAM metallopeptidase domain 8; CDH1: Cadherin 1; CRABP2: Cellular retinoic acid binding protein 2; CXCL14: C-X-C motif chemokine ligand 14; FCRL2: Fc receptor like 2; LTF: Lactotransferrin; MMP12/13: Matrix metallopeptidase 12/13; MYO6: Myosin VI; SFRP4: Secreted frizzled related protein 4; SRGAP1: SLIT-ROBO Rho GTPase activating protein 1; TOP2A: DNA topoisomerase II alpha.