Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2023; 11(23): 5504-5518
Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5504
Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis
Lin Zhang, Yuan Liu, Jian-Guo Zhuang, Jie Guo, Yan-Tao Li, Yan Dong, Gang Song
Lin Zhang, Yuan Liu, Yan-Tao Li, Yan Dong, Department of Critical Medicine, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050000, Hebei Province, China
Jian-Guo Zhuang, Department of Internal Medicine, Xiongxian Hospital of Traditional Chinese Medicine, Baoding 071800, Hebei Province, China
Jie Guo, Gang Song, Second Department of Respiratory Medicine, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050000, Hebei Province, China
Author contributions: Zhang L designed the manuscript and analyzed the data; Zhang L, Liu Y, and Zhuang JG wrote the main text; Guo J and Li YT prepared the figures and tables; Song G reviewed the manuscript; and all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: The author claims that there is no competitive advantage.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Song, MD, PhD, Chief Physician, Second Department of Respiratory Medicine, Hebei Provincial Hospital of Traditional Chinese Medicine, No. 389 Zhongshan East Road, Shijiazhuang 050000, Hebei Province, China. songgang202302@163.com
Received: May 19, 2023
Peer-review started: May 19, 2023
First decision: June 21, 2023
Revised: June 29, 2023
Accepted: July 25, 2023
Article in press: July 25, 2023
Published online: August 16, 2023
Processing time: 88 Days and 23.1 Hours
Core Tip

Core Tip: Lung cancer is an important cause of cancer-related death worldwide. This study conducted multiple bioinformatics analysis methods to explore potential therapeutic targets for lung adenocarcinoma (LUAD). Finally, three hub genes with high connectivity were identified, namely cellular retinoic acid binding protein 2, matrix metallopeptidase 12, and DNA topoisomerase II alpha. High expression of these genes was associated with a poor LUAD prognosis, and the genes exhibited high diagnostic value. Therefore, these genes may be biomarkers and therapeutic targets for LUAD.