Prevotella oris-caused meningitis and spinal canal infection: A case report

Table 1 Characteristics of infections caused by Prevotella oris

Ref.	Age/Sex	Initial symptoms	Infection site	Pathogens	Initial diagnosis	Final diagnosis	Antimicrobial treatment	Outcome
Viswanath et al[14], 2022	51/M	Right-sided chest pain	Pleura	Prevotella oris	Pulmonary tuberculosis	Pleural infection	Metronidazole (500 mg) IV twice a day initially and then continued for 5 d	Improved
Cobo et al[15], 2022	70/M	Fever, dyspnea and general malaise	Blood and liver	Prevotella oris	COVID-19 infection	Bacteremia, hepatic abscess	Initially, piperacillin-tazobactam (1 g/8 h/IV) and levofloxacin (500 mg/12 h/IV); subsequently, piperacillin-tazobactam (1 g/8 h/IV) and metronidazole (500 mg/8 h/IV) for 10 d	Recovered
Carmack et al[16], 2021	34/M	Cough, fever and night sweats	Pericardium	Prevotella oris and Fusobacterium nucleatum	Tuberculosis pericarditis	Pericarditis secondary to Prevotella oris and Fusobacterium nucleatum	Initially, rifampin, isoniazid, pyrazinamide, ethambutol (RIPE) and prednisone, then ceftriaxone and doxycycline; subsequently, ampicillin/sulbactam 3 g every 6 h	Improved
Duan et al[17], 2021	64/M	Unconsciousness, dyspnea and swelling in the mandible and neck	Mediastinum	Prevotella oris; Prevotella denticola; Streptococcus anginosus; Peptostreptococcus stomatis; Fusobacterium nucleatum; Alloprevotella tannerae	Acute purulent mediastinitis	Descending necrotizing mediastinitis	Initially, vancomycin, imipenem; subsequently, piperacillin/tazobactam and tinidazole; finally, levaquin and piperacillin/tazobactam	Improved
Bein et al[18], 2003	NA	Acute unconsciousness due to spontaneous intracerebral bleeding in the cerebellar region	Blood	Prevotella oris	Spontaneous intracerebral bleeding	Bacteremia and sepsis due to Prevotella oris from dentoalveolar abscesses	Initially, imipenem via central venous catheter; subsequently, metronidazole IV	Improved
Abufaied et al[19], 2020	42/M	Left-sided pleuritic chest pain and acute onset of left upper limb weakness	Chest	Prevotella oris	Empyema necessitans	Empyema necessitans	14 d of IV ertapenem and later 14 d of oral ciprofloxacin 500 mg two times daily and amoxicillin/clavulanic acid 625 mg three times daily at the time of discharge	Improved
Frat et al[4], 2004	61/M	Right hemiparesis and bilateral Babinski’s sign	Cervical spinal epidural space and meninges	Prevotella oris and Peptostreptococcus micros	Meningoencephalitis	Cervical spinal epidural abscess and meningitis	Initially, ceftriaxone, amoxicillin and cotrimoxazole; subsequently, fosfomycine, ceftriaxone and metronidazole for 3 wk, followed by 8 wk of oral metronidazole	Improved

COVID-19: Coronavirus disease 2019; IV: Intravenous; NA: Not available; M: Male.