Computed tomography perfusion imaging evaluation of angiogenesis in patients with pancreatic adenocarcinoma

Table 1 Demographic features

	Pancreatic adenocarcinoma (n = 35)	Controls (n = 33)	P value
Age (yr)	61.5 (46-79)	48 (28-68)	< 0.001
Gender
Male	17 (48.6%)	20 (60.6%)	0.342
Female	18 (51.4%)	13 (39.4%)
rBF	0.222 ± 0.089	1.000 ± 0.023	< 0.001
rBV	0.453 ± 0.193	0.993 ± 0.076	< 0.001
rPE	0.576 ± 0.278	1.003 ± 0.008	< 0.001
rPermeability	6.000 ± 1.395	0.949 ± 0.165	< 0.001
rTTP	1.917 ± 0.208	1.014 ± 0.039	< 0.001

rBF: Relative blood flow; rBV: Relative blood volume; rPermeability: Relative permeability; rPE: Relative peak enhancement; rTTP: Relative time to peak.

Table 2 Relative computed tomography perfusion parameters of grade I-II pancreatic adenocarcinoma vs grade III-IV pancreatic adenocarcinoma

	Grade I-II pancreatic adenocarcinoma (n = 25)	Grade III-IV pancreatic adenocarcinoma (n = 10)	P value
rBF	0.266 ± 0.057	0.111 ± 0.042	< 0.001
rBV	0.546 ± 0.127	0.223 ± 0.123	< 0.001
rPE	0.586 ± 0.265	0.552 ± 0.321	0.750
rPermeability	5.841 ± 1.413	6.393 ± 1.336	0.297
rTTP	1.919 ± 0.208	1.911 ± 0.218	0.915

rBF: Relative blood flow; rBV: Relative blood volume; rPermeability: Relative permeability; rPE: Relative peak enhancement; rTTP: Relative time to peak.

Table 3 Correlation between relative computed tomography perfusion parameters and immunohistochemical indicators in pancreatic adenocarcinoma patients

Pearson correlation	rBF	rBV	rPE	rPermeability	rTTP
VEGF	-0.670b	-0.557 b	-0.182	0.107	0.071
CD105-MVD	-0.489 b	-0.549 b	-0.002	0.016	0.030
CD34-MVD	-0.241	-0.407a	-0.074	0.072	-0.028
AR	-0.497b	-0.412a	0.049	-0.046	0.020
VMI	0.603b	0.499b	-0.119	-0.043	0.150

^aP < 0.05.

^bP < 0.01. AR: Angiogenesis rate; VMI: Vascular maturity index.