Tacrolimus treatment for relapsing-remitting chronic inflammatory demyelinating polyradiculoneuropathy: Two case reports

Table 1 Clinical features and therapeutic status of two patients with chronic inflammatory demyelinating polyradiculoneuropathy

Case	Sex/age	Disease Course (mo)	Number of recurrences	Pretreatment medication	Prednisone usage and dosage before tacrolimus	Tacrolimus		Therapeutic effect (ONLS score)
						Dosage (mg/d)	Length of treatment (mo)	Before Tacrolimus	After 6 mo treatment
1	F/17	11	4	IVIg; steroids	40 mg 4 wk, 35 mg 4 wk, 30 mg was associated with onset of symptoms	2	12	1	0
2	M/27	60	4	IVIg; steroids	-	3	6	2	0

ONLS: Overall neuropathy limitation scale; IVIg: Intravenous immunoglobulin.

Table 2 Comparison of nerve conduction velocities before and after treatment in both patients

			Case 1 (one-year)		Case 2 (one-year)
	Nerve		Before	After	Before	After
MNCV	Median	Distal latency (ms)	5.9	4.7	7.7	6.73
		Velocity (m/s)	22	35	28	38.6
	Tibial	Distal latency (ms)	6.8	7.3	8.2	8.19
		Velocity (m/s)	42	43	45	35
SNCV	Median	Distal latency (ms)	Not elicited	2.9	Not elicited	3.85
		Velocity (m/s)	Not elicited	47	Not elicited	35.8
	Tibial	Distal latency (ms)	5.5	Not performed	Not elicited	Not performed
		Velocity (m/s)	30	Not performed	Not elicited	Not performed

MNCV: Motor nerve conduction velocity; SNCV: Sensory nerve conduction velocity.