Clinical features of elderly patients with COVID-19 in Wuhan, China

Table 1 Demographic and clinical characteristics of elderly COVID-19 patients at admission¹

Characteristic	Total, n = 234	Survivors, n = 205	Deceased, n = 29	P value
Age, yr	70 (67-75)	70 (67-74)	72.0 (68.0-75.5)
Sex
Male	122 (52.1)	103 (50.2)	19 (65.5)	0.16
Female	112 (47.9)	102 (49.8)	10 (34.5)
Age range, yr
≤ 79	207 (88.5)	182 (88.8)	25 (86.2)	0.68
> 79	27 (11.5)	23 (11.2)	4 (13.8)
Comorbidities
Diabetes	50 (21.4)	40 (19.5)	10 (34.5)	0.088
Hypertension	106 (45.3)	88 (42.9)	18 (62.0)	0.07
Cardiovascular disease	30 (12.8)	25 (12.2)	5 (17.2)	0.55
Malignancy	6 (2.56)	5 (2.44)	1 (3.44)	0.55
Cerebrovascular disease	12 (5.13)	10 (4.88)	2 (6.90)	0.65
Asthma	1 (0.4)	1 (0.5)	0	> 0.99
COPD	6 (2.6)	5 (2.4)	1 (3.4)	0.55
Chronic kidney disease	6 (2.6)	6 (2.9)	0	> 0.99
Rheumatologic disease	4 (1.7)	4 (2.0)	0	> 0.99
Admission signs and symptoms
Fever	153 (65.4)	135 (65.9)	18 (62.0)	0.68
Dry cough	134 (57.3)	124 (60.5)	10 (34.5)	0.009
Shortness of breath	96 (41.0)	80 (39.0)	16 (55.2)	0.11
Chills	1 (0.4)	1 (0.5)	0	> 0.99
Fatigue	111 (47.4)	98 (47.8)	13 (44.8)	0.84
Headache	4 (1.7)	4 (2.0)	0	> 0.99
Myalgia	2 (0.9)	2 (1.0)	0	> 0.99
Diarrhea	5 (2.1)	3 (1.5)	2 (6.9)	0.12
Dyspnea	7 (3.0)	6 (2.9)	1 (3.4)	> 0.99
Body temperature, °C	36.6 (36.38-36.83)	36.5 (36.3-36.8)	36.8 (36.6-37.2)	< 0.0001
Heart rate, bpm	84 (78-89)	84 (78-88)	88 (80-92)	0.01
Respiratory rate, bpm	20 (19-22)	20 (19-22)	20 (19-22)	< 0.0001
Percutaneous oxygen saturation, %	96 (92-97.25)	96 (94-98)	83 (77.5-94.5)	< 0.0001
Clinical category
Moderate	163 (69.7)	163 (79.5)	0	NA
Severe	39 (16.7)	39 (19.0)	0	NA
Critical	32 (13.7)	3 (1.5)	29 (100)	NA

¹Data are expressed as n (%) or median (interquartile range). NA: Not available.

Table 2 Laboratory characteristics of elderly patients with COVID-19 at admission¹

Characteristic	Reference range	Total, n = 234	Survivors, n = 205	Deceased, n = 29	P value
White blood cells, × 109/L	3.5-9.5	5.9 (4.8-8.3)	5.6 (4.6-6.9)	8.4 (6.8-11.4)	< 0.0001
Lymphocytes, × 109/L	1.1-3.2	1.2 (0.9-1.6)	1.3 (1.0-1.7)	0.6 (0.4-0.9)	< 0.0001
Platelets, × 109/L	125-350	239 (177-300)	244 (186-303)	163 (112-271)	0.1400
C-reactive protein, mg/L	0-4	6.4 (1.9-34.2)	5.4 (1.6-20.7)	100.0 (25.4-153.5)	< 0.0001
D-dimer, mg/L	0-0.55	0.69 (0.44-1.24)	0.64 (0.4-1.035)	3.88 (0.895-7.245)	0.0025
Prothrombin time, s	9.2-15.0	13.2 (12.4-13.9)	13.0 (12.3-13.7)	14.7 (13.9-16.2)	< 0.0001
Activated partial thromboplastin time, s	21-37	28.3 (26.1-30.2)	28.3 (26.2-30.0)	28.8 (24.9-31.6)	0.8000
Fibrinogen, g/L	2-4	3.2 (2.8-3.7)	3.2 (2.8-3.6)	3.3 (2.8-4.2)	0.1500
Thrombin time, s	10-20	16.0 (15.1-16.9)	15.9 (15.0-16.6)	16.89 (15.7-17.9)	0.0007
Alanine aminotransferase, IU/L	9-50	23.2 (15.5-36.0)	22.3 (15.1-34.0)	31.1 (18.5-48.8)	0.0004
Aspartate aminotransferase, IU/L	15-40	21.8 (16.4-28.6)	21.4 (16.1-26.9)	30.6 (19.6-46.0)	< 0.0001
Albumin, g/L	40-55	35.1 (32.1-37.5)	35.3 (32.5-37.9)	32.7 (28.9-35.9)	0.0008
Blood glucose, mmol/L	3.9-6.1	5.1 (4.6-6.0)	5.0 (4.5-5.7)	6.9 (5.2-9.1)	< 0.0001
Blood urea nitrogen, mmol/L	2.5-6.4	4.7 (3.8-6.2)	4.6 (3.8-5.9)	6.2 (4.2-9.6)	0.0008
Creatinine, µmol/L	40-88	64.2 (56.400-76.125)	63.8 (56.5-74.9)	65.6 (56.0-81.6)	0.4300
Uric acid, µmol/L	112-416	265 (210-329)	267 (217-325)	257 (173-392)	0.4700
Creatine kinase, IU/L	24-170	43 (31-73)	41 (30-69)	46 (31-147)	< 0.0001
Lactate dehydrogenase, IU/L	120-250	199 (167-267)	194 (161-241)	354 (208-470)	< 0.0001
Creatine kinase-MB, IU/L	0-24	9.1 (7.2-12.5)	9.1 (7.0-12.0)	12.5 (8.6-20.0)	0.0008

¹Data are expressed as n (%) or median (interquartile range).