Recurrence of sigmoid colon cancer–derived anal metastasis: A case report and review of literature

Table 1 Summary of published colorectal cancer–derived anal metastasis cases

Ref.	Sex	Age	Anal disease history	Primary tumor				BVI	Lymph nodes	Anal metastasis					Follow-up time (mo) and recurrence
				Location	Surgery	Stage	Pathology			Symptoms	Time after primary surgery	Surgery	Pathology	Chemo or radiotherapy
Guiss[18], 1954	M	63	NS	SC	APR	A	NS	NS	NS	Pain, blood in stool	Synchronous	APR	NS	NS	14/NA
Killingbacket al[24], 1965	M	63	8 yr of AF	SC	APR	A	WDA	-	-	Perianal abscess	Synchronous	APR	WDA	NS	NA
Parnes[25], 1976	M	56	Yes	RS	APR	B	NS	-	-	Perianal abscess	3 mo	LR	NS	No	18/NA
Rollinson et al[26], 1984	M	65	20 yr of AF	RS	APR	NS	MDA	-	-	Perianal abscess	Synchronous	APR	MDA	No	10/NA
Norgren et al[11], 1985	M	60	No	R	AR	B	MDA	-	-	Perianal abscess, blood in stool	4 mo	LR	MDA	NS	NS
Scott et al[14], 1988	F	70	No	SC	SCR	B	NS	-	-	Pain, blood in stool	3 mo	LR	NS	No	NS
Thomas et al[9], 1992	M	68	17 yr of AF	SC	APR	B	MDA	NS	NS	Perianal abscess with mass	Synchronous	APR	MDA	NS	NS
Wind et al[27], 1999	M	70	No	R	LAR	A	MDA	-	-	No	6 mo	LR	MDA	No	30/NA
Isbister[13], 2000	M	39	1 yr of AF	SC	Hartmann	C	MDA	-	+	Pain	12 mo	LR	MDA	No	NS
	M	47	20 yr of AF	RS	AR	C	MDA	-	+	Perianal abscess	12 mo	No	MDA	No	NS
	M	69	20 yr of AF	SC	SCR	C	NS	+	+	Perianal mass	synchronous	No	NS	No	NS
Shinohara et al[28], 2001	M	36	16 yr of AF	R	AR	C	MDA	+	+	No	21 d	LR	MDA	NS	6/liver metastasis
Kouraklis et al[29], 2002	M	75	1 yr of AF	RS	APR	B	MDA	-	-	Perianal abscess	Synchronous	APR	MDA	NS	NS
Hyman et al[30], 2003	M	66	15 yr of AF	SC	APR	B	MDA	-	-	Perianal abscess	Synchronous	APR	MDA	NS	12/NA
Gupta et al[8], 2005	M	44	NS	DC	DCR	C	MDA	-	-	Perianal abscess	Synchronous	LR	MDA	NS	36/NA
Hamada et al[17], 2005	M	53	7 yr of AF	RS	AR	B	W	-	-	Blood in stool	20 d	LR	WDA	After surgery	12/NA
Ishiyama et al[19], 2006	M	53	20 yr of AF	R	LAR	C	MDA	-	+	Pain	Synchronous	LR	MDA	NS	10/death due to peritoneal metastasis
Sandiford et al[31], 2006	M	72	7 yr of AF	RS	SCR + LR	C	MDA	-	-	Blood in stool, diarrhea	Synchronous	SCR + LR	NS	After surgery	14/NA
Gravante et al[15], 2008	M	64	No	DC	DCR	A	MDA	-	-	No	1 mo	APR	MDA	After surgery	14/NA
Wakatsuki et al[32], 2008	M	57	7 yr of AF	RS	AR	C	MDA	-	+	Anal mass	27 mo	LR	MDA	NS	43/NA
Yokoyama et al[33], 2010	M	72	NS	SC	SCR	C	MDA	-	+	Blood in stool	26 mo	APR	MDA	NS	132/Lung metastasis
Takahashi et al[34], 2011	M	61	5 yr of AF	RS	APR	C	MDA	+	+	Anal mass	Synchronous	APR	MDA	Before surgery	36/NA
	M	47	No	SC	Pelvic lymphadenectomy	C	MDA	+	+	Perianal abscess	Synchronous	APR	MDA	Before surgery	87/NA
	M	59	No	R	AR	C	MDA	-	+	Anal mass	6 mo	APR	MDA	After surgery	3/NA
Benjelloun et al[35], 2012	M	55	10 yr of AF	RS	AR + LR	B	WDA	-	-	Anal mass	Synchronous	AR + LR	WDA	Before surgery	36/NA
	M	68	No	RS	AR + LR	B	WDA	-	-	Perianal abscess	Synchronous	AR + LR	WDA	Before surgery	36/NA
Hakoda et al[36], 2017	M	65	NS	R	AR	C	MDA	+	+	Pain	18 mo	APR	MDA	NS	18/NA
Fathallah et al[6], 2018	M	49	No	SC	SCR	C	MDA	-	+	Perianal abscess, diarrhea	Synchronous	No	MDA	Before surgery	NS
Ikeda et al[5], 2019	M	69	Yes	RS	Hartmann	B	WDA	-	-	Perianal abscess	1 mo	LR	WDA	Before surgery	31/NA
Badiani et al[37], 2020	M	70	No	RS	APR	B	MDA	-	-	Blood in anus	Synchronous	APR	MDA	Before surgery	NS
Our case	M	80	No	SC	SCR	C	MDA	-	+	Perianal abscess	12 mo	LR	MDA	After surgery	10 yr/recurrence
Recurrence										Perianal abscess	10 yr	LR	MDA	No	5/death due to MLD

M: Male; F: Female; NS: Not specified; AF: Anal fistula; DC: Descending colon; SC: Sigmoid colon; RS: The junction of the rectum and sigmoid colon; R: Rectum; APR: Abdominoperineal resection; SCR: Sigmoid colon resection; AR: Anterior resection; LAR: Low anterior resection; DCR: Descending colon resection; LR: Local resection; BVI: Blood vessel invasion; WDA: Well differentiated adenocarcinoma; MDA: Moderately differentiated adenocarcinoma; NA: Not available.