Meng LK, Zhu D, Zhang Y, Fang Y, Liu WZ, Zhang XQ, Zhu Y. Recurrence of sigmoid colon cancer–derived anal metastasis: A case report and review of literature. World J Clin Cases 2022; 10(3): 1122-1130 [PMID: 35127928 DOI: 10.12998/wjcc.v10.i3.1122]
Corresponding Author of This Article
Yong Zhu, PhD, Chief Doctor, Department of Colorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing 210022, Jiangsu Province, China. zhuyong839@sina.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ling-Kang Meng, Dan Zhu, Yu Zhang, Yuan Fang, Wei-Zhen Liu, Xia-Qing Zhang, Yong Zhu, Department of Colorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, Jiangsu Province, China
Author contributions: Meng LK analyzed the data and drafted the manuscript; Zhu D and Zhang Y collected the data; Fang Y and Liu WZ performed pathological evaluations; Zhang XQ analyzed the results of diagnostic imaging; Zhu Y revised the manuscript; all authors read and approved the final version of the manuscript.
Supported byNanjing Municipal Health Bureau, No. NWQR-201702; and Nanjing Translational Medicine Base of Chinese Medicine, No. ZHZD201802.
Informed consent statement: Written informed consent was obtained from the patient‘s next of kin, for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Conflict-of-interest statement: The authors declare no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Zhu, PhD, Chief Doctor, Department of Colorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing 210022, Jiangsu Province, China. zhuyong839@sina.com
Received: July 14, 2021 Peer-review started: July 14, 2021 First decision: October 22, 2021 Revised: October 26, 2021 Accepted: December 25, 2021 Article in press: December 25, 2021 Published online: January 21, 2022 Processing time: 184 Days and 23.3 Hours
Abstract
BACKGROUND
Distant metastasis of colorectal cancer to the anus is very rare, with only 30 related cases published in PubMed thus far. Therefore, recurrence of colorectal cancer derived anus metastases is rarely seen and less presented.
CASE SUMMARY
Here we report an 80-year-old male patient who underwent radical resection for sigmoid colon cancer in January 2010 and another surgery for anal fistula resection in December 2010. Postoperative pathology of the anal fistula revealed a metastatic moderately differentiated adenocarcinoma. The patient subsequently received chemotherapy and radiotherapy. In May 2020, after the patient reported symptoms of anal swelling and pain, computed tomography and magnetic resonance imaging revealed a perianal abscess. Perianal mass biopsy was performed, and the postoperative pathological diagnosis was metastatic moderately differentiated adenocarcinoma.
CONCLUSION
This case highlights that there is a risk of recurrence of anal metastasis of colorectal cancer even after 10 years of follow-up. We also reviewed the literature and discuss potential mechanisms for anal metastasis of colorectal cancer, thus providing some suggestions for treatment of these cases.
Core Tip: Metastasis of colorectal cancer to the anus is very rare. We describe a patient who had a local anal metastatic recurrence after chemotherapy and local anal radiotherapy. This case highlights that there is a risk of recurrence of anal metastasis of colorectal cancer even after 10 years of follow-up.
