Case Report
Copyright ©The Author(s) 2022.
World J Clin Cases. Oct 16, 2022; 10(29): 10575-10582
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10575
Table 1 Reports on liver tumors with triple (hepatocellular, cholangiocellular, and neuroendocrine) differentiation
Cases of liver tumors with triple differentiation described in the literature
Two Chinese male patients (average age: 57.5 yr) were positive for hepatitis B and exhibited hepatic tumors with triple differentiationHe et al[18], 2013
A healthy 19-year-old Caucasian man developed a large hepatic tumor showing triple differentiationBeard et al[16], 2017
A 65-year-old woman with a history of hepatitis C and rectal “carcinoid” developed a hepatic tumor with triple differentiationDimopoulos et al[17], 2021
A 32-year-old Chinese man with a history of hepatitis B and wine-drinking exhibited hepatic tumors with triple differentiationCurrent case report
Table 2 Partial clinical data of patients
Age (yr)
Site of primary lesion
AFP (μg/L)
Male61ChinaLiverB12105%Surgical resection + TACEShort
Male 54ChinaLiverB140080%Surgical resection + TACE2 mo
Male19United StatesLiver/NormalHighSurgical resection + Cisplatin and gemcitabine chemotherapy> 8 mo
Female65United StatesRectumC2198HighSurgical resection + Cisplatin and gemcitabine chemotherapy5 mo
Male32United StatesLiverB451960%Surgical resection + TACE4 mo