Case Report
Copyright ©The Author(s) 2022.
World J Clin Cases. Sep 26, 2022; 10(27): 9936-9944
Published online Sep 26, 2022. doi: 10.12998/wjcc.v10.i27.9936
Table 1 Laboratory and serological test findings representative of atypical or interstitial pneumonia at admission
Recorded value
Standard range
White blood cell count8310/µL4500-7500/µL
Hemoglobin11.8 g/dL11.3-15.2 g/dL
Platelet count23.2 × 103/µL13-35 × 103/µL
Total protein6.9 g/dL6.9-8.4 g/dL
Albumin3.5 g/dL3.9-5.1 g/dL
Total bilirubin0.7 mg/dL0.2-1.2 mg/dL
Aspartate aminotransferase31 U/L11-30 U/L
Alanine aminotransferase26 U/L4-30 U/L
Lactase dehydrogenase368 U/L109-216 U/L
Blood urea nitrogen 9.6 mg/dL8-20 mg/dL
Creatinine0.5 mg/dL0.63-1.03 mg/dL
Sodium 135 mEq/L135-145 mEq/L
Potassium 4.2 mEq/L3.6-5.2 mEq/L
Chlorine98 mEq/L98-108 mEq/L
C-reactive protein31.65 mg/L≤ 1.0 mg/L
Procalcitonin0.66 ng/mL≤ 0.3 ng/mL
KL-6205 U/mL≤ 500 U/mL
Surfactant protein A105.9 ng/mL≤ 43.8 ng/mL
Surfactant protein D105.3 ng/mL≤ 110 ng/mL
C3136 mg/dL86-160 mg/dL
C428.7 mg/dL17-45 mg/dL
IgG1137 mg/dL870-1700 mg/dL
IgA193 mg/dL110-410 mg/dL
IgM134 mg/dL35-220 mg/dL
ACE15.2 U/mL8.3-21.4 U/mL
Antinuclear antibody< 40< 40
RF< 3 U/mL0-15 U/mL
Anti-CCP antibody0.8 U/mL< 5 U/mL
Anti-Ro/SS-A antibodyNegativeNegative
Anti-La/SS-B antibodyNegativeNegative
Anti-Jo-1 antibodyNegativeNegative
Anti-ARS antibodyNegativeNegative
Orientia tsutsugamushi Karp IgG< 10< 10
Orientia tsutsugamushi Karp IgM< 10< 10
Orientia tsutsugamushi Kato IgG< 10< 10
Orientia tsutsugamushi Kato IgM< 10< 10
Orientia tsutsugamushi Gilliam IgG< 10< 10
Orientia tsutsugamushi Gilliam IgM< 10< 10
C. pneumoniae IgGNegativeNegative
C. pneumoniae IgANegativeNegative
CMV-IgM< 0.850-0.7
M. pneumoniae PCR of the sputumNegativeNegative
Urine Legionella antigen testingNegativeNegative
Beta-D-glucan assay9.0 pg/mL
Aspergillus IgGNegativeNegative
Anti-Trichosporon asahii antibodyNegativeNegative
Table 2 Clinical characteristics of patients with reported acetaminophen-induced lung injury
Age (years)
Time between drug use and presentation (d)
Time between initial diagnosis and drug discontinuation (d)
1Female20JapaneseAcetaminophen (Norshin®) Fever, cough, and dyspnea20Drug discontinuation; CorticosteroidsDisease resolutionKitaguchi et al[10], 1992
2Female63JapaneseAcetaminophen (Caronal®)Cough and dyspnea810Drug discontinuation; CorticosteroidsDisease resolutionKudeken et al[11], 1993
3Male45JapaneseAcetaminophen (PL Combination Granules®)Fever, cough, and diarrhea40Drug discontinuationDisease resolutionNakatsumi et al[12], 1994
4Male75JapaneseAcetaminophen (Pabron gold®/Pabron S®)Fever and dyspnea30Drug discontinuation; CorticosteroidsDisease resolutionNomura et al[13], 1997
5Male57JapaneseAcetaminophen (PL Combination Granules® /Shin Lulu A Tablets®)Fever, cough, and dyspnea118 monthsDrug discontinuation; CorticosteroidsRespiration and disease resolutionKawano et al[14], 1997
6Female64JapaneseAcetaminophen (Caronal®)Fever, cough, and dyspnea198Drug discontinuation; CorticosteroidsDisease resolutionAkashi et al[15], 1997
7Female70JapaneseAcetaminophen (Caronal®)Fever, cough, and dyspnea65Drug discontinuation; CorticosteroidsDisease resolutionNakajima et al[16], 1998
8Female49JapaneseAcetaminophen (Benza Block SP®)Fever and dyspnea55Drug discontinuation; CorticosteroidsDisease resolutionNakajima et al[16], 1998
9Male72JapaneseAcetaminophen (PL Combination Granules®)Fever and dyspnea10Drug discontinuation; CorticosteroidsRespiration and Disease resolutionIkeuchi et al[17], 2000
10Male31JapaneseAcetaminophen (PL Combination Granules®)Fever and cough1331Drug discontinuationdisease resolutionHiramatsu et al[18], 2002
11Female68JapaneseAcetaminophen (PL Combination Granules®)Fever, cough, and dyspnea60Drug discontinuation; Corticosteroids, CyclosporineDisease resolutionNakayama et al[19], 2006
12Female41JapaneseAcetaminophen (Ibuprofen®/Caronal®)Fever, cough, and dyspnea30Drug discontinuation; CorticosteroidsDisease resolutionAnan et al[20], 2009
13Female84 JapaneseAcetaminophen (Shin Lulu A Tablets s®)Fever, cough, and dyspnea50Drug discontinuation; CorticosteroidsDisease resolutionKato et al[21], 2010
14Female80 JapaneseAcetaminophen (Caronal®)Fever and dyspnea150Drug discontinuation; CorticosteroidsDisease resolutionSasaki et al[22], 2014
15Female68CaucasianAcetaminophen (Caronal®)Cough and dyspneaMonthsNot specifiedDrug discontinuationDisease resolutionSaint-Pierre et al[23], 2016
16Female79JapaneseAcetaminophen (Caronal®)Dyspnea20Drug discontinuation; CorticosteroidsDisease resolutionUeda et al[24], 2019
Present caseFemale35 JapaneseAcetaminophen (Caronal®)Fever411Drug discontinuationDisease resolution-