Noncirrhotic portal hypertension due to peripheral T-cell lymphoma, not otherwise specified: A case report

Table 1 Main laboratory test results

Laboratory tests	Result	Reference value
White blood cell count	1.80 × 109/L	3.5-9.5 × 109/L
Neutrophil count	1.33 × 109/L	1.8-6.3 × 109/L
Neutrophil percentage	0.738	40-75%
Haemoglobin	71 g/L	115-150 g/L
Platelet count	54 × 109/L	100-300 × 109/L
Albumin	26.5 g/L	40.0-55.0 g/L
Lactate dehydrogenase	347 IU/L	120-250 IU/L
Erythrocyte sedimentation rate	3.0 mm/h	< 38 mm/h
Coagulation function revealed a prothrombin time of	18.2 s	9.6-12.8 s
Fibrinogen	0.64 g/L	2.0-4.0 g/L

Table 2 Immunohistochemistry of pleural fluid, ascites, liver, and bone marrow

Parameter	Marrow	Ascites	Hydrothorax	Liver
CD2	++	+	+	-
CD3	++	++	+	+
CD4	-	-	-	-
CD5		+	+	+
CD7	++	++	++	+
CD8	+	+	++	+
CD11c	-	-
CD16	-	+	-
CD30				-
CD34				-
CD38		-	++
CD43				+
CD45		+
CD56	++	++	++	+
CD57	+	+p	++
TCRαβ	+	+
TCRγδ	-	-
TIA-1				-
TDT				-
Ki-67				+

“+” indicates positive, the number indicates positive degree; “-” indicates negative; blank indicates that the examination was not performed.

Table 3 A summary of demographic, radiographic, and clinical information from a review of five previously published cases of T-cell lymphomas with ascites and/or portal hypertension manifestations

Ref.	Age, Gender	Course of disease	Clinical Symptoms	Supplementary Examination	Biopsy Source	Immunohistochemistry	Diagnosis	Invasion of other parts	Treatment	Prognosis
Ameri[13]	61, F	2+W	Abdominal discomfort	Ascites, hepatosplenomegaly	Ascites	CD4(+), CD2(+), CD5(+), CD3(+), CD7(-), CD16(-), CD56(-), CD57(-), TdT(-)	PTCL, NOS	Bone marrow	No treatment	NA
Yamamoto[10]	72, W	3+W	Abdominal discomfort	Hydrothorax and ascites	Ascites	CD2 (+), CD3(+) (+),CD45(+), CD4 (–), CD8 (–)	PTCL	Thorax and abdomen	Cyclophosphamide, mitoxantrone, vincristine, etoposide, bleomycin, and prednisolone	Died of multiple organ failure
Izban[12]	76, F		Abdominal tenderness	Ascites, splenomegaly	Ascites	CD2(+), CD3(+), CD5(+), CD7(+), CD45(+), CD4(-), CD8(-)	PTCL	Bone marrow, liver	CHOP chemotherapy	Recurrence after chemotherapy
VakarLópez[11]	49, W	3+M	Abdominal tenderness	Ascites	Ascites	CD3(+)	PTCL, NOS		No treatment	NA
Lindor[9]	65, F	2+Y	Pectoralgia, esophageal and gastric variceal bleeding (EGVB)	Splenomegaly, EGVB	spleen	NA	Diffuse mixed-type T-cell lymphoma		Splenectomy	Bone marrow infiltration occurred 1 + year after the operation

PTCL: Peripheral T-cell lymphoma; NOS: Not otherwise specified.