Published online Sep 16, 2022. doi: 10.12998/wjcc.v10.i26.9417
Peer-review started: April 25, 2022
First decision: June 8, 2022
Revised: June 20, 2022
Accepted: August 5, 2022
Article in press: August 5, 2022
Published online: September 16, 2022
Peripheral T-cell lymphoma (PTCL), an aggressive and rare disease that belongs to a heterogeneous group of mature T-cell lymphomas, develops rapidly and has a poor prognosis. Early detection and treatment are essential to improve patient cure and survival rates. Here, we report a rare case of PTCL with clinical presentation of noncirrhotic portal hypertension, which provides a basis for early vigilance of lymphomas in the future.
A 65-year-old Chinese woman was admitted to our hospital because of abdominal distension for 3 months and pitting oedema of both lower limbs for 2 months. Physical examinations and associated auxiliary examinations showed the presence of hepatosplenomegaly, and her hepatic venous pressure gradient was 10 mmHg. Immunohistochemical analysis of the liver biopsy confirmed the diagnosis of PTCL. The patient underwent combination therapy with dexame
PCTL accompanied by noncirrhotic portal hypertension is rarely reported. This case report discusses the diagnosis of a patient according to the literature.
Core Tip: Peripheral T-cell lymphoma (PTCL) is an aggressive and rare disease that belongs to a heterogeneous group of mature T-cell lymphomas, and is classified as PTCL, not otherwise specified (PTCL-NOS). It is the most common type and most often involves nodal sites; however, many patients present with extranodal involvement, including the liver, bone marrow, gastrointestinal tract, and skin. The clinical presentations of PTCL are lymphadenopathy syndrome and B symptoms (night sweats, fever, and weight loss). Noncirrhotic portal hypertension, hydrothorax and ascites can also occur in rare cases, and noncirrhotic portal hypertension and ascites are less common as first symptoms. Here, we report a rare case of a patient with PTCL who presented with noncirrhotic portal hypertension.