Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

Table 1 Chemical composition information of zedoary turmeric and trisomes

No.	Compound ID	Compound name	Oral bioavailability (%)	Dibenzodiazepines	Herbs
1	MOL001297	Trans-gondoic acid	30.7	0.20	Trisomes
2	MOL000358	Beta-sitosterol	36.91	0.75	Trisomes
3	MOL000392	Formononetin	69.67	0.21	Trisomes
4	MOL000449	Stigmasterol	43.83	0.76	Trisomes
5	MOL000296	Hederagenin	36.91	0.75	Trisomes, zedoary turmeric

Table 2 Degree information of compounds and targets

No.	Node	Degree	No.	Node	Degree
1	Hederagenin	24	26	OPRM1	2
2	Beta-sitosterol	23	27	BCL2	2
3	Formononetin	23	28	BAX	2
4	Stigmasterol	21	29	CASP9	2
5	Trans-gondoic acid	5	30	CASP3	2
6	PTGS1	7	31	CASP8	2
7	CHRM1	7	32	PRKCA	2
8	PTGS2	7	33	PON1	2
9	GABRA1	6	34	NOS2	2
10	PGR	5	35	ESR1	2
11	CHRM3	5	36	AR	2
12	ADRA1B	5	37	ESR2	2
13	SCN5A	5	38	MAPK14	2
14	RXRA	5	39	GSK3B	2
15	ADH1C	4	40	PRSS1	2
16	ADRA1A	4	41	CCNA2	2
17	ADRB2	4	42	ACHE	2
18	LYZ	3	43	IL4	2
19	SLC6A4	3	44	NR3C2	2
20	JUN	3	45	ADRA2A	2
21	PPARG	3	46	AKR1B1	2
22	SLC6A3	3	47	PLAU	2
23	MAOB	3	48	LTA4H	2
24	KCNH2	2	49	ADRB1	2
25	CHRNA2	2