Effects of alendronate sodium combined with InterTan on osteoporotic femoral intertrochanteric fractures and fracture recurrence

doi:10.12998/wjcc.v10.i21.7324

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Clin Cases. Jul 26, 2022; 10(21): 7324-7332
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7324

Table 1 Comparison of general information between the two groups, n (%)

Material	Control group (n = 63)	Observation group (n = 63)	χ²	P value
Gender			0.519	0.471
Male	38 (60.32)	34 (53.97)
Female	25 (39.68)	29 (46.03)
Age (yr)			0.037	0.847
< 60	19 (30.16)	20 (31.75)
≥ 60	44 (69.84)	43 (68.25)
Affected side			0.286	0.593
Left	34 (53.97)	31 (49.21)
Right	29 (46.03)	32 (50.79)
AO typing			0.140	0.710
A2 type	42 (66.67)	40 (63.49)
A3 type	21 (33.33)	23 (36.51)
Cause of injury			1.685	0.640
Fall	21 (33.33)	26 (41.27)
Traffic accident	23 (36.51)	18 (28.57)
Fall from height	15 (23.81)	13 (20.63)
Other	4 (6.35)	6 (9.52)
Combined diseases
Coronary heart disease	14 (22.22)	12 (19.05)	0.194	0.660
Diabetes	11 (17.46)	9 (14.29)	0.238	0.626
Hypertension	15 (23.81)	18 (28.57)	0.370	0.543
Hyperlipidemia	8 (12.70)	11 (17.46)	0.558	0.455

Table 2 Comparison of surgical indicators between the two groups (mean ± SD)

Groups	Operation time (min)	Intraoperative bleeding (mL)	Postoperative landing time (d)	Fracture healing time (mo)
Control group (n = 63)	75.25 ± 5.96	52.36 ± 11.47	7.06 ± 1.85	3.35 ± 0.29
Observation group (n = 63)	73.89 ± 6.08	51.74 ± 13.36	6.98 ± 1.91	3.04 ± 0.23
t value	1.268	0.279	0.239	6.648
P value	0.207	0.780	0.817	0.000

Table 3 Comparison of co-occurrence between the two groups, n (%)

Groups	Bedsore	Urinary tract infection	Pulmonary infection	Incision infection	Total complications
Control group (n = 63)	1 (1.59)	1 (1.59)	2 (3.17)	1 (1.59)	5 (7.94)
Observation group (n = 63)	1 (1.59)	1 (1.59)	1 (1.59)	0 (0.00)	3 (1.76)
t value					0.534
P value					0.465

Table 4 Comparison of bone metabolism markers between the two groups (mean ± SD)

Groups	β-CTX (ng/L)			T-PINP (μg/L)
Groups	Preoperative	3 mo after operation	12 mo after operation	Preoperative	3 mo after operation	12 mo after operation
Control group (n = 63)	345.85 ± 85.23	321.25 ± 71.36	304.58 ± 68.45^a	21.45 ± 5.26	22.58 ± 6.04	25.89 ± 5.12^a
Observation group (n = 63)	351.14 ± 79.92	261.25 ± 64.74^a	162.25 ± 51.33^a	21.37 ± 5.08	26.14 ± 4.86^a	29.85 ± 4.75^a
t value	0.359	4.943	13.204	0.087	3.645	4.500
P value	0.720	0.000	0.000	0.931	0.000	0.000

^aP < 0.05 vs before operation.

β-CTX: β-Collagen-specific sequence; T-PINP: Total aminoterminal propeptide of type I procollagen.

Table 5 Comparison of t-values of hip bone mineral density between the two groups (mean ± SD)

Groups	Preoperative	After operation
Groups	Preoperative	1 mo	3 mo	6 mo	12 mo
Control group (n = 63)	-2.61 ± 0.18	-2.55 ± 0.19	-2.53 ± 0.17^a	-2.34 ± 0.16^a	-2.08 ± 0.13^a
Observation group (n = 63)	-2.60 ± 0.15	-2.21 ± 0.22^a	-2.02 ± 0.15^a	-1.61 ± 0.11^a	-1.37 ± 0.10^a
t value	0.339	9.284	17.855	29.842	34.360
P value	0.735	0.000	0.000	0.000	0.000

^aP < 0.05 vs before operation.

Table 6 Comparison of Harris scores between the two groups (mean ± SD)

Groups	Preoperative	After operation
Groups	Preoperative	1 mo	3 mo	6 mo	12 mo
Control group (n = 63)	34.25 ± 3.05	71.14 ± 4.06^a	78.65 ± 3.58^a	81.05 ± 4.06^a	83.36 ± 3.64^a
Observation group (n = 63)	34.18 ± 3.21	79.53 ± 4.51^a	86.54 ± 4.12^a	88.96 ± 4.11^a	91.23 ± 4.52^a
t value	0.125	10.974	11.474	10.868	10.764
P value	0.900	0.000	0.000	0.000	0.000

^aP < 0.05 vs before operation.

Table 7 Comparison of recurrence of fractures in the two groups within 12 mo, n (%)

Groups	Recurrent fracture
Control group (n = 63)	4 (6.35)
Observation group (n = 63)	0 (0.00)
χ²	4.131
P value	0.042

Citation: Wang KM, Wei SP, Yin XY, Meng QJ, Kong YM. Effects of alendronate sodium combined with InterTan on osteoporotic femoral intertrochanteric fractures and fracture recurrence. World J Clin Cases 2022; 10(21): 7324-7332
URL: https://www.wjgnet.com/2307-8960/full/v10/i21/7324.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i21.7324