Ovarian teratoma related anti-N-methyl-D-aspartate receptor encephalitis: A case series and review of the literature

Table 1 Year of publication and country of study of patients with anti-N-methyl-D-aspartate receptor encephalitis and ovarian teratoma

Year of publication and country of study
Year of publication (No. of papers)	n (%)
2014 (17)	22 (14.2)
2015 (19)	20 (12.9)
2016 (28)	31 (20.0)
2017 (32)	38 (24.5)
2018 (17)	18 (11.6)
2019 (17)	26 (16.8)
Total (130)	155 (100.0)
Country of birth or study	n (%)
Asia: Japan-28; China-26; Korea-5; India-5; Taiwan-3; Thailand-2; Malaysia-1; Saudi Arabia-1; Israel-1	72 (46.5)
Australia: 5	5 (3.2)
Europe: Spain-12; United Kingdom-6; Italy-3; Netherlands-3; Poland-2; Russia-2; Germany-1; France-1; Hungary-1; Ireland-1; Croatia-1; Turkey-1; Espana-1; Romania-1; Osterreich-1	37 (23.9)
North-America: United States-36; Canada-3; Mexico-1	40 (25.8)
South-America: Ecuador-1	1 (0.6)
Total	155 (100)

Table 2 Age of patients, histological type of ovarian teratoma, laterality of the affected ovary, and tumor size

Variable	Histological type of ovarian teratoma				Total cases with teratoma
	Mature	Immature	Mature and immature	Not specified
Age (n)	130	14	2	9	155
mean ± SD	25.1 ± 8.3	24.8 ± 7.1	23.0 ± 0.0	25.2 ± 8.0	25.0 ± 8.0
Median (min-max)	25 (7-73)	25 (9-38)	23 (23-23)	25 (14-36)	25 (7-73)
Tumor location
Right ovary	56 (88.9)	6 (9.5)	0	1 (1.6)	63
Left ovary	38 (86.4)	6 (13.6)	0	0	44
Bilateral	18 (85.7)	0	2 (9.5)	1 (4.8)	21
Not marked	18 (66.7)	2 (7.4.)	0	7 (25.9)	27
Total
Teratoma size (cm)
mean ± SD (n)	3.3 ± 2.4 (65)	10.2 ± 3.9 (10)	3.5 ± 1.3 (2)	-	4.1 ± 3.3 (77)
Median (min-max)	3.4 (0.4-13)	10.2 (2.5-17)	3.5 (2.4-4.9)	-	5.7 (0.4-17)

Table 3 Surgery and outcome

Outcome type	Tumor excision	Oomph	Surgery type not specified	No surgery	Not specified
Full recovery	37	27	7
Mild deficits	18	9	1
Severe deficits	1		1		1
Death	1	2		4
Not specified	11	29	6