Reduced serum high-density lipoprotein cholesterol levels and aberrantly expressed cholesterol metabolism genes in colorectal cancer

Table 1 Factors related to serum cholesterol levels in patients with colorectal cancer

Project	Gender	Age (60 year)	BMI (24 kg/m2)	Smoking	Drinking	Stage	Tumor size (5 cm)
TC	0.001	0.373	0.502	0.575	0.606	0.448	0.360
TG	0.188	0.912	< 0.001	0.917	0.378	0.768	0.852
HDL-C	< 0.001	< 0.001	< 0.001	0.008	0.496	0.042	0.016
LDL-C	0.027	0.498	0.078	0.630	0.879	0.250	0.929
TC/LDL-C	0.544	0.575	0.118	0.755	0.750	0.797	0.259
TC/HDL-C	0.031	0.001	< 0.001	0.020	0.099	0.008	0.019
LDL-C/HDL-C	0.067	0.014	< 0.001	0.075	0.254	0.018	0.008

TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol.

Table 2 Relationship between colorectal tumor size and serum cholesterol level

Project (size)	< 5 cm (n = 560)	≥ 5 cm (n = 283)	P value
TC	4.62 ± 0.95	4.56 ± 0.91	0.354
TG	1.38 ± 0.8	1.36 ± 0.95	0.782
HDL-C	1.25 ± 0.35	1.18 ± 0.41	0.009
LDL-C	3.06 ± 0.86	3.06 ± 0.82	0.965
TC/LDL-C	1.56 ± 0.26	1.53 ± 0.24	0.242
TC/HDL-C	3.93 ± 1.26	4.19 ± 1.33	0.009
LDL-C/HDL-C	2.61 ± 0.96	2.83 ± 1.1	0.004

TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol.

Table 3 Relationship between colorectal tumor staging and serum cholesterol levels

Project (stage)	I (n = 151)	II (n = 296)	III (n = 340)	IV (n = 56)	P value
TC	4.61 ± 0.86	4.55 ± 0.88	4.65 ± 1.01	4.30 ± 0.94	0.395
TG	1.44 ± 0.95	1.31 ± 0.79	1.4 ± 0.87	1.09 ± 0.85	0.228
HDL-C	1.3 ± 0.35	1.22 ± 0.38	1.2 ± 0.37	1.24 ± 0.37	0.045
LDL-C	3.01 ± 0.78	3.04 ± 0.8	3.11 ± 0.91	2.81 ± 0.85	0.427
TC/LDL-C	1.57 ± 0.18	1.54 ± 0.22	1.55 ± 0.3	1.58 ± 0.25	0.689
TC/HDL-C	3.78 ± 1.17	3.96 ± 1.15	4.19 ± 1.44	3.65 ± 1.29	0.006
LDL-C/HDL-C	2.5 ± 0.95	2.66 ± 0.97	2.8 ± 1.06	2.4 ± 1.01	0.014

TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol.