Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients: A case report and review of literature

Table 1 Clinical features of 5 meningioma patients in the study

Case No.	Sex/age	Symptom	Meningioma location	WHO grade of meningioma	Second primary tumor	Operation	Surgical approach	Simpson grade	Recurrence	Postoperative treatment	Follow-up, mo
1	F/45	Seizure	Left frontal parafalcine	I	Subependymoma	Synchronous	TC	II	None	None	27
2	F/40	Headache	Right middle cranial fossa	I	Pituitary adenoma	Synchronous	TS + TC	II	None	None	24
3	M/48	Headache	Tuberculum sellae	I	Pituitary adenoma	Synchronous	TC	II	None	None	23
4	F/52	Blurred vision, headache	Left sphenoid ridge	I	Pituitary adenoma	Synchronous	TC	II	Growth of residual pituitary tumor after 4 mo	Radiotherapy	24
5	F/29	Amenorrhea and headache	Left petroclival	I	Pituitary adenoma	Synchronous	TC	IV	None	None	96

F: Female; M: Male, TC: Transcranial surgery; TS: Transsphenoidal surgery; WHO: World Health Organization.

Table 2 Summary of coexisting meningioma and pituitary adenoma

No.	Ref.	Age	Sex	Symptom	Size of meningioma, cm	Type of meningioma	Location of meningioma	Type of pituitary adenoma	History of radiation	Treatment	Postoperative therapy
1	Love et al[19], 1955	65	F	NA	NA	Meningothelial	Sylvian fissure	Non-secreting	NA	NA	NA
2	O’Connell[20], 1961	47	F	Failing vision in right eye	NA	Meningothelial	Tuberculum sellae	Non-secreting	No	TC (MN + PA)	No
3	Kitamura et al[21], 1965	66	F	Headache and impaired vision	NA	Meningothelial	Sphenoid wing	Non-secreting	No	TC (MN + PA)	No
4	Probst[22], 1971	48	F	NA	NA	Meningothelial	Suprasellar	ACTH-producing	NA	NA	NA
5	Brennan et al[23], 1977	36	M	Blurred vision of right eye	NA	Transitional	Sphenoid wing	Non-secreting	No	TC (MN + PA)	Radiotherapy
6	Bunick et al[24], 1978	57	M	Intermittent right-sided headache, acromegaly	6 × 6	Fibrous	Right frontal lobe	GH-producing	No	TC (MN + PA)	No
7	Hainer et al[25], 1978	72	M	NA	NA	NA	Suprasellar	GH-producing	NA	NA	NA
8	Deen et al[26], 1981	75	F	Chronic dementia, only had postmortem examination	NA	NA	Right sphenoid ridge	NA	NA	Autopsy	No
9	Hyodo et al[27], 1982	52	F	Acromegaly, diabetes mellitus, headache, right hemiparesis and right impaired visual acuity	NA	Fibrous and meningothelial	Left parietal region	GH-producing	No	TC (MN) + TS (PA, 4 mo later)	No
10	Irsy et al[28], 1985	59	F	NA	NA	NA	Centro-parietal	GH-producing	NA	NA	NA
11	Ohata[29], 1985	50	F	Acromegaly, visual disturbance, headache, vomiting and a floating sensation	4 × 4 × 4	Transitional	Falcotentorial junction	GH-producing	No	TS (PA) + TC (MN, 2 mo later)	Bromocriptine, acetylcortisone, desiccated thyroid
12	Yamada et al[30], 1986	52	F	Headache, disturbance of visual acuity and galactorrhea	NA	Meningothelial	Sphenoid ridge (parasellar)	Non-secreting	No	TC (PA + MN)	Bromocriptine
13	Honegger et al[31], 1989	37	F	Marked alopecia	2.5	Meningothelial	Right temporal pole	PRL-producing	No	TC (MN)	Bromocriptine
14	Honegger et al[31], 1989	49	F	Acromegaly persisted after radiotherapy	3	Meningothelial	Left parasagittal	GH-producing	Yes	TS (PA) + TC (MN, 2 mo later)	No
15	Honegger et al[31], 1989	74	M	Recurrence of pituitary adenoma	1.5	NA	Left parietal	Non-secreting	Yes	TS (PA) + TC (PA, 5 yr later)	No
16	Zentner et al[32], 1989	46	M	CT demonstration of a large intrasellar and suprasellar space-occupying lesion	1.5	Transitional	Planum sphenoidale	PRL-producing	No	TC (PA + MN)	No
17	Zentner et al[32], 1989	63	F	Ataxia	NA	Meningothelial	Sphenoid wing	Non-secreting	No	TS (PA) + TC (MN, 1 mo later)	No
18	Zentner et al[32], 1989	61	F	Frontal headache	NA	Meningothelial	Infradiaphragmatic	Non-secreting	No	TS + TS (PA + MN) + TC (PA, 1 d later)	No
19	Partington et al[2], 1989	26	M	Evaluation of persistent symptom of Cushing’s disease; left temporal hemianopsia (10 yr later)	NA	Meningothelial	Tuberculum sellae	ACTH-secreting	Yes	TS (PA) + TS (PA, 8 yr later) + TC (1 yr later)	No
20	Uno et al[33], 1991	70	F	Headache and acromegaly	NA	Meningothelial	Sphenoid ridge	GH-producing	No	TC (MN + PA)	No
21	Cannavo et al[34], 1993	47	F	Acromegaly, diminished visual acuity, weakness and headache	NA	Meningothelial	Right latero- and retrosellar	GH-producing	No	TC (PA + MN)	No
22	Abs et al[35], 1993	47	F	Aphasia and temporary right-sided hemiparesis	NA	Meningothelial	Tuberculum sellae	PRL-producing	No	TC (MN) + TS (PA, 3 mo later)	No
23	Abs et al[35], 1993	61	F	A toxic thyroid adenoma, Cushing’s disease	NA	Meningothelial; transitional	Frontal convexity; occipital convexity	ACTH-producing	No	TC (MN)	No
24	Abs et al[35], 1993	45	F	Amenorrhea and galactorrhea	NA	NA	Temporal fossa	PRL-producing	No	No surgery	No
25	Abs et al[35], 1993	45	F	A toxic multinodular goiter and suspicion of acromegaly	NA	NA	Parietal convexity	GH-producing	No	TC (Schwannoma) + TS (PA)	No
26	Abs et al[35], 1993	82	F	Bitemporal hemianopsia	NA	NA	Sphenoid ridge; parasellar	Non-secreting	No	TS (PA)	No
27	Abs et al[35], 1993	61	F	Headache	2.6	NA	Choroid plexus (right lateral ventricle)	PRL-producing	No	No surgery	No
28	Abs et al[35], 1993	51	F	Unilateral palpebral edema and exophthalmos	NA	NA	Sphenoid wing	Non-secreting	No	Embolization (MN)	No
29	Gorge et al[36], 1993	53	M	Progressive impotence, decrease of libido and left-sided defective vision	NA	NA	Para- and suprasellar	PRL-producing	NA	TC (PA + MN)	No
30	Laun et al[37], 1993	61	F	Deteriorating vision of the left eye and bitemporal hemianopia	NA	Meningothelial	Tuberculum sellae	Non-secreting	NA	NA	No
31	Mathuriya et al[38], 2000	58	F	Acromegaly	NA	NA	Parasagittal	GH-producing	No	TC (PA + MN)	Radiotherapy
32	Maiuri et al[39], 2005	49	M	Acromegaly, right hemiparesis	3.5	NA	NA	GH-producing	No	TC (MN) + TS (PA, 3 mo later)	No
33	Maiuri et al[39], 2005	63	F	Left hemiparesis, bitemporal visual field defect	4	NA	NA	Non-secreting	No	TC (MN) + TS (PA, 1 mo later)	No
34	Curto et al[40], 2007	61	F	Acromegaly and visual field impairment	3.5	NA	Right frontal	GH-producing	No	NA	No
35	da Costa et al[41], 2007	45	M	Generalized malaise and weight loss for a few months. Progressive headache, vomiting and gait ataxia for 2 wk	NA	NA	The fourth ventricle	PRL-producing	No	TC (MN)	Bromocriptine
36	Prevedello et al[42], 2007	52	F	Unremitting headache and profound right temporal visual field loss	1.0 × 0.6	NA	Right planum sphenoidale	Non-secreting	No	TS (PA + MN)	No
37	Basu et al[43], 2010	39	M	Frontal headaches and erectile dysfunction with loss of libido	NA	Meningothelial	Left cavernous sinus	PRL-secreting	No	TC (MN)	No
38	Furtado et al[12], 2010	53	M	Headache for 2 yr and altered sensorium for 2 wk	6.0 × 5.5 × 5.0	Meningothelial	Parasagittal	Non-secreting	No	TS (PA) + TC (MN)	No
39	Guaraldi et al[44], 2012	46	F	Acromegaly	2.3 × 2.6 × 2.6	NA	Left parasagittal	GH-producing	No	TS (PA) + TC (MN, 10 yr later) + TS (Recurrence PA, 8 mo later)	No
40	Ramirez et al[45], 2012	61	F	Headache and acute hydrocephalus for 2 mo	1.0 × 1.0	Psammomatous	Left anterior clinoidal	Silent corticotroph adenoma subtype II	No	TC (MN) + TS (PA, 1 mo later)	No
41	Masoodi et al[46], 2013	65	M	Acromegaly	NA	NA	Frontal parasagittal	GH-producing	No	TS (PA) + TC (MN)	No
42	Mahvash et al[47], 2014	36	F	Frontal headache and extended right visual field loss	2.0 × 2.0 × 2.5	NA	Tuberculum sellae	Non-secreting	No	TS (PA + MN)	No
43	Karsy et al[48], 2014	70	F	Altered mental status, mutism and incontinence	3.6 × 4.1 × 4.5	Fibroepithelial	Tuberculum sellae	Non-secreting	No	TS (PA + MN)	No
44	Ruiz-Juretschke et al[49], 2015	61	M	Progressive visual loss and bitemporal hemianopia for 6 mo	2.0 × 2.2 × 2.2	Meningothelial	Tuberculum sellae and planum sphenoidale	Non-secreting	No	TS (PA + MN) + TS (residual tumor)	No
45	Ben Nsir et al[50], 2016	61	F	Loss of vision for 3 yr and occasional episode headache	NA	NA	Foramen magnum	Non-secreting	No	TC (MN) + [TS + TC] (PA)	No
46	Lim et al[51], 2016	65	F	Visual symptoms and an episode of self-resolving vertigo	1.5 × 1.3 × 1.3; 0.6 × 0.5	NA	Tuberculum sellae and olfactory groove	Non-secreting	No	TS (PA + MN)	No
47	Amirjamshidi et al[3], 2017	37	F	Oligomenorrhea for 8 mo, headache, diplopia and progressive visual impairment	3.0 × 2.5 × 2.0	NA	Suprasellar	PRL-secreting	No	TC (MN)	No
48	Amirjamshidi et al[3], 2017	42	M	Acromegaly, visual acuity decreased and bitemporal hemianopia	3.0 × 3.0 × 2.0	NA	Suprasellar	Non-secreting	No	TS + TC (coexisting tumors)	No
49	Herrero-Ruiz et al[52], 2017	35	F	Chagas disease and acromegaly	2.0 × 2.0 × 1.2	NA	Left parietal parasagittal	GH-producing	No	TS (Only PA)	No
50	Kumaria et al[53], 2017	46	F	Lethargy, sleep disturbance, personality change and mild daily right-sided headache for 18 mo	NA	Transitional; Atypical	Right frontal and left temporal regions	Mammosomatotroph cell adenoma (PRL- and GH-secreting)	Yes	TC (MN) + TC (MN) + TS (PA)	No
51	Zhao et al[54], 2017	58	F	Acromegaly and headache	NA	NA	Sellar	GH-producing	No	TS (PA) + TC (MN, 3 mo later)	No
52	Zhao et al[54], 2017	58	F	Acromegaly	NA	NA	Sellar	GH-producing	No	TS (PA) + TC (MN, 4 mo later)	No
53	de Vries et al[4], 2019	75	F	Depression, fatigue and unintended weight loss	NA	Meningothelial	Suprasellar	Non-secreting	No	TS (PA + MN)	No

ACTH: Adrenocorticotropic hormone; CT: Computed tomography; GH: Growth hormone; F: Female; M: Male; TC: Transcranial surgery; TS: Transsphenoidal surgery; MN: Meningioma; NA: Not available; PA: Pituitary adenoma; PRL: Prolactin.