Hu TH, Wang R, Wang HY, Song YF, Yu JH, Wang ZX, Duan YZ, Liu T, Han S. Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients: A case report and review of literature. World J Clin Cases 2022; 10(13): 4249-4263 [PMID: 35665119 DOI: 10.12998/wjcc.v10.i13.4249]
Corresponding Author of This Article
Sheng Han, Doctor, MD, PhD, Academic Research, Surgeon, Surgical Oncologist, Department of Neurosurgery, The First Hospital of China Medical University, No. 155 Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. hansheng@cmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 6, 2022; 10(13): 4249-4263 Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4249
Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients: A case report and review of literature
Tian-Hao Hu, Run Wang, Hai-Yun Wang, Yi-Fu Song, Juan-Han Yu, Zi-Xun Wang, Yu-Zhou Duan, Ting Liu, Sheng Han
Tian-Hao Hu, Run Wang, Hai-Yun Wang, Yi-Fu Song, Zi-Xun Wang, Yu-Zhou Duan, Sheng Han, Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Juan-Han Yu, Department of Pathology, China Medical University, Shenyang 110001, Liaoning Province, China
Ting Liu, Department of Radiology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Hu TH, Wang R, Duan YZ, Liu T and Han S performed the data acquisition and prepared the figures; Hu TH, Wang HY and Song YF prepared the manuscript and followed up the patients; Yu JH and Wang ZX performed histopathology examination of the patients; Hu TH and Han S designed the report; All authors contributed to the article and approved the submitted version.
Supported bythe LiaoNing Revitalization Talents Program, No. XLYC1807253; and the National Natural Science Foundation of China, No. 81772653.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng Han, Doctor, MD, PhD, Academic Research, Surgeon, Surgical Oncologist, Department of Neurosurgery, The First Hospital of China Medical University, No. 155 Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. hansheng@cmu.edu.cn
Received: October 2, 2021 Peer-review started: October 2, 2021 First decision: October 22, 2021 Revised: October 29, 2021 Accepted: March 15, 2022 Article in press: March 15, 2022 Published online: May 6, 2022 Processing time: 210 Days and 1.4 Hours
Abstract
BACKGROUND
The coexistence of meningioma and other intracranial primary benign tumors is rare, especially in non-neurofibromatosis type 2, and there is limited guidance for the management of such patients. Here, we report a series of 5 patients with concomitant meningioma and other intracranial benign tumors, including subependymoma and pituitary adenoma.
CASE SUMMARY
Five non-neurofibromatosis type 2 patients with simultaneous occurrence of meningioma and other intracranial benign tumors were retrospectively reviewed. The patients had no history of previous irradiation. The clinical features, pre- and postoperative imaging, surgical procedure and pathological findings were extracted from electronic medical records. There were 4 female patients (80%) and 1 male patient (20%). The mean age was 42.8 years (range: 29-52 years). The coexisting tumors included subependymoma in 1 case (20%) and pituitary adenoma in 4 cases (80%). The most common clinical symptom was headache (3/5, 60%). Four patients (80%) underwent craniotomy. One patient (20%) underwent transsphenoidal surgery followed by transcranial operation. All tumor diagnoses were confirmed by histopathological examination. The mean follow-up was 38.8 mo (range: 23-96 mo), and all 5 patients were in a stable condition at the last follow-up.
CONCLUSION
The simultaneous occurrence of meningioma and other intracranial benign tumors is a rare clinical event. Histological examination is necessary for the accurate diagnosis. Neurosurgeons should select the appropriate surgical strategy according to the clinical features of each patient, which may provide a more favorable prognosis for individual patients.
Core Tip: The simultaneous occurrence of meningioma and other intracranial primary benign tumors is rare, especially in non-neurofibromatosis type 2, and there is limited guidance for the management of such patients. In this study, we report a series of 5 patients with coexistence of meningioma and other intracranial benign tumors, including subependymoma and pituitary adenoma.
