Primitive neuroectodermal tumor of the prostate in a 58-year-old man: A case report

Table 1 Reported 18 cases of primitive neuroectodermal tumor in the prostate: Demographics and clinical features

No.	Ref.	Age	Symptoms	PSA (ng/mL)	Size (cm)	Immunohistochemistry (positive)	Molecular studies	Treatment	Follow-up (mo)	Metastases
1	Colecchia et al[1], 2003	31	NA	2.06	7	CD99, vimentin, NSE, synaptophysin	EWS/FLI1 fusion	CT, RT, SR	NA	NA
2	Peyromaure et al[21], 2003	27	Dysuria and pelvic discomfort	NA	NA	CD99	t (11; 22) (q24; q12)	CT, SR, RT	2+	NA
3	Thete et al[10], 2007	26	Dysuria and pelvic discomfort	0.3	NA	CD99(Mic-2)	NA	NA	NA	NA
4	Kumar et al[16], 2008	25	Burning micturition and dysuria	0.88	6.7	CD99, vimentin, S100, NSE, synaptophysin	NA	CT	NA	NA
5	Funahashi et al[13], 2009	20	Gross hematuria and miction pain	0.7	10	CD99, NSE, CD56, MIB-1, p53	t (11; 22) (q24; q12)	SR	10+	Lung
6	Mohsin et al[14], 2011	29	Burning micturition and urinary retention	1.3	NA	CD99	NA	CT	4	Lung
7	Al Haddabi et al[4], 2012	24	Dysuria, constipation, back pain, and pelvic discomfort	0.7	10	CD99, Bcl2, CK19, AE1/AE3, CK, vimentin	Rearrangement of chromosome 22	CT	NA	No
8	Wu et al[5], 2013	29	Difficult defecation and anus distention	1.19	7.4	CD99, Bcl-2	NA	SR, CT	12+	Lung
9	Liao et al[17], 2015	49	Frequent urination, dysuria, and pelvic discomfort	NA	7.1	CD99, CD56, NSE, Ki-67	NA	CT, RT	24+	No
10	Shibuya et al[3], 2015	23	Dysuria and anal pain	NA	NA	MIC-2, cytokeratin, vimentin, N-CAM	Translocation at chromosome 22q12	CT	4	Bone, lung, meninge
11	Esch et al[11], 2016	33	Pelvic pain, dysuria, and urgency	NA	6	Cytokeratin	EWSR1-gene	SR	12+	No
12	Kord et al[8], 2018	38	Abdominal pain, constipation, pain with defecation, and hematuria	NA	14.4	CD99	EWSR1/FLI1 fusion	CT, SR	14	Lung, liver, peritoneum
13	Du et al[9], 2019	39	Notalgia and paraplegia	1.07	2.6	CD99, CD56, P63, vimentin	NA	RT, CT	17	Thoracic spine
14	Javanmard et al[22], 2019	37	Painless gross hematuria	1.07	8.6	CD99, vimentin, BCL2, Ki67	NA	SR, CT	16	Yes
15	Liu et al[23], 2020	40	Dysuria	NA	11.2	CD99, synaptophysin, CD56, vimentin	FLI1	SR, CT	14+	No
16	Teng et al[15], 2020	27	Dysuria and dyschezia	1.52	8.4	CD99, CD56, desmin, vimentin	NA	SR	5	Lung and peritoneum
17	da Ponte et al[12], 2021	29	Pelvic discomfort and dysuria	0.4	8.8	CD99/MIC-2, synaptophysin	EWS gene rearrangement	CT, SR	84+	No
18	Present case	58	Dysuria, constipation, and pain with defecation	0.82	10.8	CD99, vimentin, synaptophysin	NA	SR, CT	34+	No

NA: Not available; PSA: Prostate specific antigen; NSE: Neuron specific enolase; EWS: Ewing's sarcoma; N-CAM: Neural cell adhesion molecule; CT: Chemotherapy; RT: Radiotherapy; SR: Surgical resection.