Effect of enhanced recovery after surgery on inflammatory bowel disease surgery: A meta-analysis

Table 1 Characteristics of the studies included in the meta-analysis

Ref.	Year	Study date	Study design	Single/Multi center	Disease type	Country	Sample size	NOS
Spinelli et al[24]	2012	January 2008 to September 2011	Retrospective	Multi center	CD	Italy	90	7
Mineccia et al[25]	2020	May 2007 to December 2018	Observational	Single center	CD	Italy	94	8
Liska et al[26]	2019	January 2015 to April 2017	Retrospective	Single center	CD and UC	United States	671	8
D'Andrea et al[27]	2020	January 2013 to December 2018	Retrospective	Single center	CD and UC	United States	753	8
Zhu et al[28]	2018	December 2015 to December 2016	RCT	Single center	CD	China	32	8
Vrecenak et al[29]	2014	December 2000 to December 2010	Retrospective	Single center	CD	United States	71	7
West et al[30]	2013	January 2005 to January 2011	Retrospective	Multi center	CD and UC	United Kingdom	68	8
Meunier et al[16]	2021	November 2015 to December 2019	Retrospective	Multi center	Unknown	France	160	8

CD: Crohn's disease; RCT: Randomized controlled trial; UC: Ulcerative colitis; NOS: Newcastle-Ottawa scale.

Table 2 Summary of characteristics between enhanced recovery after surgery group and non-enhanced recovery after surgery group

Characteristics	Studies	Participants, ERAS/Non-ERAS	Odds ratio/mean difference (95%CI)	Heterogeneity
Baseline information
Age, yr	2	256/587	0.35 (-1.72, 2.78); P = 0.65	I2 = 0%; P = 0.59
Male	7	644/1135	1.20 (0.98, 1.46); P = 0.08	I2 = 0%; P = 0.74
BMI, kg/m2	3	272/603	-0.56 (-1.19, 0.06); P = 0.08	I2 = 12%; P = 0.32
ASA 1-2	4	549/1059	0.91 (0.73, 1.14); P = 0.41	I2 = 0%; P = 0.77
ASA 3-4	4	510/1059	1.10 (0.88, 1.37); P = 0.41	I2 = 0%; P = 0.77
Laparoscopic surgery	4	563/1023	1.47 (0.90, 2.38); P = 0.12	I2 = 62%; P = 0.05
Open surgery	4	460/1023	0.68 (0.42, 1.11); P = 0.12	I2 = 62%; P = 0.05
Surgical outcomes
Operation time	2	256/587	-0.17 (-23.45, 23.10); P = 0.99	I2 = 78%; P = 0.03
Time to first flatus	2	36/86	-2.03 (-3.89, -0.17); P = 0.03	I2 = 94%; P < 0.01
Time to bowel movement	3	81/112	-1.08 (-1.60, -0.57); P < 0.01	I2 = 71%; P = 0.03
Post-operative hospital stay	4	317/629	-1.99 (-3.27, -0.71); P < 0.01	I2 = 89%; P < 0.01
Anastomotic fistula	6	639/1200	0.36 (0.13, 0.95); P = 0.04	I2 = 0%; P = 0.70
Bleeding	4	358/568	1.16 (0.48, 2.76); P = 0.75	I2 = 0%; P = 0.80
Readmission rate	7	673/1234	0.72 (0.51, 1.00); P = 0.05	I2 = 0%; P = 0.87

ASA: American Association of Anesthesiologists; BMI: Body mass index; CI: Confidence interval; ERAS: Enhanced recovery after surgery.