Concurrent chemoradiotherapy using gemcitabine and nedaplatin in recurrent or locally advanced head and neck squamous cell carcinoma

Table 1 Baseline and clinical characteristics of patients

Characteristics	Number (n)	Percentage (%)	Characteristics	Number (n)	Percentage (%)
Age, yr			Sex
Mean	59.8 ± 8.08		Male	16	0.67
Range	37.1-66.2		Female	8	0.33
T stage			N stage
1	1	0.042	1	5	0.208
2	9	0.375	2	17	0.708
3	4	0.167	3	2	0.083
4	10	0.417	Differentiation
Smoking history			High	1	0.042
Nonsmoker	7	0.292	Moderately	3	0.125
20-30 yr	11	0.458	Low	12	0.5
30-39 yr	1	0.042	Uncertain	8	0.333
> 40 yr	5	0.208	Primary tumor site
History of alcohol use			Nasopharynx	9	0.375
Nondrinker	3	0.125	Larynx	5	0.208
Infrequent (< once/wk)	8	0.333	Hypopharynx	3	0.125
Light (< 3 times/wk)	2	0.083	Oral Cavity	2	0.083
Moderate (> 3 times/wk but < once/d)	6	0.25	Tongue	2	0.083
Heavy (> once/d)	5	0.208	Esophagus	2	0.083
Disease situation			Nasal cavity	1	0.042
Recurrence	10	0.417	AJCC stage
Local advancement	14	0.583	III	8	0.333
ECOG PS			IVA	13	0.542
0	0	0	IVB	3	0.125
1	22	0.917	Pre-treatment
2	2	0.083	Surgery	10	0.417
			Radiotherapy	20	0.167
			Chemotherapy	5	0.208

ECOG PS: Eastern cooperative oncology group performance status; AJCC: American joint committee on cancer.

Table 2 Therapeutic evaluation

Indexes	Number (n)	Percentage (%)
CR	8	33.3
PR	16	66.7
SD	0	0
ORR	24	100
DCR	24	100

CR: Complete response; PR: Partial response; SD: Stable disease; ORR: Objective response rate; DCR: Disease control rate.

Table 3 Adverse event (n = 24)

Adverse events		Grade
	1	2	3	4	1-4	3-4
Hematologic	2	5	7	11	24 (100%)	18 (75%)
Leukopenia	1	5	14	4	24 (100%)	18 (75%)
Neutropenia	7	4	9	1	21 (87.5%)	10 (41.7%)
Thrombocytopenia	6	3	6	7	22 (91.7%)	13 (54.2%)
Anemia	10	10	4	0	24 (100%)	4 (16.7%)
Mucositis	0	4	2	15	21 (87.5%)	17 (70.8%)
Fatigue	10	9	0	0	19 (79.2%)	0 (0%)
Nausea	2	10	0	0	12 (50%)	0 (0%)
Pain	1	8	3	0	12 (50%)	3 (12.5%)
Infection	4	6	2	0	12 (50%)	2 (8.3%)
Electrolyte disturbance	6	2	4	0	12 (50%)	4 (16.7%)
Dermatitis	8	1	0	2	11 (45.8%)	2 (8.3%)
Constipation	10	2	0	0	12 (50%)	0 (0%)
Hemorrhage	1	0	2	1	4 (16.7%)	3 (12.5%)
Hepatotoxicity	14	4	1	0	19 (79.2%)	1 (4.2%)
Renal toxicity	2	0	0	0	2 (8.3%)	0 (0%)
Cardiotoxicity	0	0	2	4	6 (25%)	6 (25%)
Xerostomia	4	0	0	0	4 (16.7%)	0 (0%)
Neuropathy	5	1	0	0	6 (25%)	0 (0%)