Effects of physical exercise on the quality-of-life of patients with haematological malignancies and thrombocytopenia: A systematic review and meta-analysis

Table 1 Search strategy in Pubmed (similar search run in Cochrane Library and EMBASE)

Search strategy in Pubmed	Similar search run in Cochrane Library and EMBASE
Hematologic malignancy	Title/Abstract
Hematologic malignancies	Title/Abstract
Hematological malignancy	Title/Abstract
Hematological malignancies	Title/Abstract
Hematopoietic malignancies	Title/Abstract
Hematopoietic malignancy	Title/Abstract
Haematological cancer	Title/Abstract
Hematologic cancer	Title/Abstract
Hematopoietic cancer	Title/Abstract
Leukaemia	Title/Abstract
Leukemia	Title/Abstract
Myeloma	Title/Abstract
Lymphoma	Title/Abstract
Hematopoietic stem cell transplantation	Title/Abstract
1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14
Aerobic exercises	All fields
Resistance exercises	All fields
Physical exercises	All fields
Exercise intervention	All fields
Physical activity	All fields
16 OR 17 OR 18 OR 19 OR 20
Quality of life	Title/Abstract
15 AND 21 AND 22

Table 2 Characteristics of randomized controlled trial

Ref.	Year	Country	Assigned group	Randomly assigned participants (N)	Types of any participants	Intervention time	Outcomes
Jarden et al[28]	2009	Copenhagen	Control: Eoutine care	16	Adult patients scheduled for a myeloablative allo-HSCT platelets > 20 × 109/L	6 mo	Quality of life (EORTC QLQ-C30): (1) At 3 mo, case (65.1 ± 15.9) vs control (51.9 ± 20.2); P = 0.841; (2) At 6 mo, case (72.8 ± 20.0) vs control (58.3 ± 21.5); P = 0.603
			Experimental: Stretching exercises; resistance training; relaxation and psychoeducation	13
Baumann et al[29]	2010	Germany	Control: Routine care	25	Adult patients with the indication of an HSCT platelets > 30 × 109/L	The entire hospitalization phase	Quality of life (EORTC QLQ-C30): Case (61.2 ± 22.8) vs control (61.7 ± 22.1); P = 0.926
			Experimental: Aerobic endurance, training and ADL-training	24
Baumann et al[30]	2011	Germany	Control: Routine care	16	Adult patients undergoing an allo-HSCT platelets > 10 × 109/L	The whole inpatient time	Quality of life (EORTC QLQ-C30): Case (68.6± 11.2) vs control (56.3 ± 17.6)
			Experimental: Aerobic endurance, training and ADL-training, interval training, resistance training	17
Oechsle et al[31]	2014	Germany	Control: Routine care	24	Adult patients with acute myeloid leukemia platelets > 20 × 109/L	During the hospitalization 21 d (range: 16-33 d)	Quality of life (EORTC QLQ-C30): Case 50 vs control 50. P = 0.66
			Experimental: Endurance training, resistance exercises	24
Bryant et al[32]	2018	United States	Control: Routine care	9	Adult newly diagnosed with acute leukemia platelets > 10 × 109/L	During the hospitalization	PROMIS short form measures, self-reported measures of HRQOL
			Experimental:Aerobic training, resistance training	8
Wehrle et al[33]	2019	Germany	Control: Routine care	8	Adult patients diagnosed with AL platelets > 10 × 109/L	During induction chemotherapy	Quality of life (EORTC QLQ-C30): Case 1 62.5 (45.8-70.8) case 2 50.0 (33.3-58.3); vs control 66.7 (45.8-66.7)
			Experimental 1: Aerobic training	8
			Experimental 2: Resistance training	6
Pahl et al[34]	2020	Germany	Control: Routine care	23	Adult patients during allo-HSCT, platelets > 20 × 109/L	During the hospitalization	After hospitalization, CG patients reported reduced QoL (P = 0.015), IG’s QoL remained unchanged

QoL: Quality of life; PROMIS: Patient-Reported Outcomes Measurement Information System; allo-HSCT: Allogeneic hematopoietic stem cell transplant; ADL: Activities of daily living; AL: Acute leukemia; WBV: Whole body vibration; CG: Control group; IG: Intervention group; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30; HRQOL: Health-related quality of life.