Yang YP, Pan SJ, Qiu SL, Tung TH. Effects of physical exercise on the quality-of-life of patients with haematological malignancies and thrombocytopenia: A systematic review and meta-analysis. World J Clin Cases 2022; 10(10): 3143-3155 [PMID: 35647113 DOI: 10.12998/wjcc.v10.i10.3143]
Corresponding Author of This Article
Tao-Hsin Tung, PhD, Director, Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150 Ximen Road, Linhai 317000, Zhejiang Province, China. ch2876@yeah.net
Research Domain of This Article
Health Care Sciences & Services
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 6, 2022; 10(10): 3143-3155 Published online Apr 6, 2022. doi: 10.12998/wjcc.v10.i10.3143
Effects of physical exercise on the quality-of-life of patients with haematological malignancies and thrombocytopenia: A systematic review and meta-analysis
Yu-Pei Yang, Department of Hematology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Shuang-Jun Pan, Department of Neurosurgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Shu-Lin Qiu, Institute for Hospital Management, Tsing Hua University, Shenzhen 518055, Guangdong Province, China
Tao-Hsin Tung, Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China
Author contributions: Yang YP and Pan SJ conducted the study and drafted the manuscript; Pan SJ participated in the design and data collection of the study; Yang YP and Qiu SL calculated the results of this study; Tung TH conceived the study and participated in its design and coordination; all of the authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao-Hsin Tung, PhD, Director, Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150 Ximen Road, Linhai 317000, Zhejiang Province, China. ch2876@yeah.net
Received: August 13, 2021 Peer-review started: August 13, 2021 First decision: October 20, 2021 Revised: November 2, 2021 Accepted: January 25, 2022 Article in press: January 25, 2022 Published online: April 6, 2022
Abstract
BACKGROUND
Annually, there are an estimated 1187000 new patients worldwide diagnosed with haematological malignancies. Effective strategies are needed to alleviate side effects and prevent the physical and psychosocial degeneration of patients in active treatment for haematological malignancies.
AIM
To explore the effects of physical exercise on quality of life (QoL) of patients with haematological malignancies and thrombocytopenia.
METHODS
Cochrane Library, PubMed and Embase were searched for all relevant articles reporting randomized controlled trials (RCTs) that were published up to 31 July 2021. Two authors independently selected articles in accordance with the inclusion criteria, evaluated their quality, and collected information. Any controversy was resolved through discussion with a third senior author. The PRISMA 2009 checklist was followed.
RESULTS
Seven RCTs were selected in the systematic review and three were included in the final meta-analysis. There were significant differences in QoL between physical exercise groups [mean score difference = 8.81; 95% confidence interval (CI): 1.81-15.81, P = 0.01], especially in emotional functioning (mean score difference = 12.34; 95%CI: 4.64-20.04, P = 0.002) and pain (mean score difference = –12.77; 95%CI: -3.91 to -21.63, P = 0.005).
CONCLUSION
Physical exercise has clinical effects on QoL and improves emotional function and pain indices of patients with haematological malignancies and thrombocytopenia.
Core Tip: Effective strategies are needed to alleviate side effects and prevent the physical and psychosocial degeneration of patients in active treatment for haematological malignancies. This meta-analysis examined the effects of physical exercise on quality of life (QoL) of patients with haematological malignancies and thrombocytopenia. The results indicated that physical exercise improves the QoL of these patients, especially in terms of emotional functioning and pain management.
