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©The Author(s) 2022.
World J Clin Cases. Jan 7, 2022; 10(1): 128-135
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.128
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.128
Table 1 Characteristics of the patients (n = 140)
Characteristic | Mild illness (n = 114) | Severe illness (n = 26) | P value |
Age (yr, %) | 43.2 ± 14.0 | 54.7 ± 13.8 | 0.98 |
Female (n, %) | 56 (49.1) | 9 (34.6) | 0.20 |
Comorbidities (n) | |||
Hypertension | 22 (19.3) | 10 (38.5) | 0.07 |
Diabetes | 5 (4.4) | 1 (3.8) | 1.0 |
Chronic obstructive pulmonary disease | 3 (2.6) | 0 | 1.0 |
Chronic renal failure | 0 | 2 (7.7) | 1.0 |
Coronary heart disease | 1 (0.9) | 2 (7.7) | 0.09 |
Malignant tumor | 2 (1.8) | 2 (7.7) | 0.16 |
Hepatitis B | 10 (8.8) | 3 (11.5) | 0.71 |
Connective tissue disease | 1 (0.9) | 0 | 0.08 |
Gout | 2 (1.8) | 1 (3.8) | 0.46 |
Symptoms (n, %) | |||
Fever | 86 (75.4) | 24 (92.3) | 0.06 |
Cough | 61 (53.5) | 21 (80.8) | 0.01 |
Expectoration | 34 (29.8) | 17 (65.4) | < 0.01 |
Fatigue | 15 (13.2) | 5 (19.2) | 0.53 |
Chest pain | 2 (1.8) | 2 (7.7) | 0.16 |
Myalgia | 8 (7.0) | 2 (7.7) | 1.0 |
Headache | 5 (4.4) | 1 (3.8) | 1.0 |
Sore throat | 14 (12.3) | 2 (7.7) | 0.74 |
Shortness of breath | 7 (6.1) | 8 (30.8) | < 0.01 |
Diarrhea | 12 (10.5) | 2 (7.7) | 1.0 |
Table 2 Laboratory test results of the patients (n = 140)
Mild illness (n = 114) | Severe illness (n = 26) | P value | |
Leukocyte count (× 109/L) | 5.01 ± 1.85 | 4.67 ± 1.84 | 0.398 |
Neutrophil count (× 109/L) | 3.15 ± 1.41 | 3.55 ± 1.88 | 0.308 |
Lymphocyte count (× 109/L) | 1.4 ± 0.59 | 0.74 ± 0.31 | < 0.001 |
Hemoglobin (g/L) | 136.13 ± 14.43 | 130.73 ± 15.18 | 0.09 |
Platelet count (× 109/L) | 201.48 ± 72.45 | 164.35 ± 62.69 | 0.017 |
Alanine aminotransferase (U/L) | 29.26 ± 29.67 | 35.69 ± 25.43 | 0.309 |
Aspartate transaminase (U/L) | 27.97 ± 17.45 | 41.54 ± 26.22 | 0.017 |
Total serum protein (g/L) | 70.27 ± 5.08 | 65.38 ± 5.19 | < 0.001 |
Albumin (g/L) | 45.71 ± 33.39 | 37.42 ± 3.55 | 0.209 |
Prealbumin (g/L) | 198.66 ± 50.55 | 123.13 ± 47.11 | < 0.001 |
Blood urea nitrogen (mmol/L) | 3.71 ± 5.96 | 5.96 ± 10.91 | 0.303 |
Blood creatinine (μmol/L) | 172.63 ± 34.15 | 159.24 ± 433.95 | 0.319 |
Blood uric acid (μmol/L) | 241.84 ± 89.51 | 194.92 ± 96.27 | 0.019 |
Creatine kinase (U/L) | 103.54 ± 180.73 | 211.49 ± 379.39 | 0.168 |
Lactate dehydrogenase (U/L) | 202.94 ± 63.87 | 299.35 ± 68.82 | < 0.001 |
C-reactive protein (mg/L) | 14.61 ± 19.35 | 52.48 ± 29.63 | < 0.001 |
Erythrocyte sedimentation rate (mm/h) | 23.68 ± 14.36 | 33.25 ± 15.00 | 0.003 |
Arterial partial pressure of oxygen (kPa) | 13.23 ± 4.00 | 11.06 ± 2.91 | 0.01 |
Oxygenation index (mmHg) | 460.80 ± 138.71 | 324.62 ± 61.52 | < 0.001 |
Table 3 Radiologic characteristics of the patients (n = 140)
Mild illness (n = 114) | Severe illness (n = 26) | P value | |
Affected sites (n, %) | |||
Left upper lobe | 90 (78.9) | 16 (61.5) | 0.08 |
Left lower lobe | 107 (93.9) | 23 (88.5) | 0.39 |
Right upper lobe | 86 (75.4) | 14 (53.8) | 0.052 |
Right middle lobe | 73 (64.0) | 19 (73.1) | 0.49 |
Right lower lobe | 105 (92.1) | 22 (84.6) | 0.26 |
Bilateral lungs | 109 (95.6) | 26 (100.0) | 0.58 |
Features (n, %) | |||
Irregular patches | 110 (96.5) | 23 (88.5) | 0.12 |
Ground-glass opacity | 90 (78.9) | 6 (23.1) | < 0.0001 |
Consolidation | 29 (25.4) | 26 (100.0) | < 0.0001 |
Nodules | 12 (10.5) | 0 | 0.12 |
Wedge-shaped opacity | 1 (0.9) | 4 (15.4) | 0.004 |
Pleural effusion | 3 (2.6) | 8 (30.8) | < 0.0001 |
- Citation: Jin ZM, Shi JC, Zheng M, Chen QL, Zhou YY, Cheng F, Cai J, Jiang XG. Increased levels of lactate dehydrogenase and hypertension are associated with severe illness of COVID-19. World J Clin Cases 2022; 10(1): 128-135
- URL: https://www.wjgnet.com/2307-8960/full/v10/i1/128.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i1.128