Case Report Open Access
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2021; 9(26): 7954-7958
Published online Sep 16, 2021. doi: 10.12998/wjcc.v9.i26.7954
Subcutaneous angiolipoma in the scrotum: A case report
Shu-Lin Li, Jia-Wei Zhang, Yu-Qi Wu, Ke-Shi Lu, Pei Zhu, Xiang-Wei Wang
Shu-Lin Li, Jia-Wei Zhang, Yu-Qi Wu, Ke-Shi Lu, Pei Zhu, Xiang-Wei Wang, Department of Urology, Shenzhen University General Hospital, Shenzhen 518055, Guangdong Province, China
Shu-Lin Li, Jia-Wei Zhang, Yu-Qi Wu, Ke-Shi Lu, Pei Zhu, Xiang-Wei Wang, Clinical Medical Academy Center, Shenzhen University, Shenzhen 518055, Guangdong Province, China
ORCID number: Shu-Lin Li (0000-0002-4840-5221); Jia-Wei Zhang (0000-0002-7252-866X); Yu-Qi Wu (0000-0001-8854-064X); Ke-Shi Lu (0000-0001-7680-8434); Pei Zhu (0000-0002-8625-7354); Xiang-Wei Wang (0000-0001-8108-4979).
Author contributions: Li SL drafted the manuscript; Zhang JW managed the patient; Wu YQ, Lu KS, Wang XW, and Zhu P participated in the surgery; Zhu P supervised the manuscript writing; all authors have read and approved the final manuscript.
Supported by Science and Technology Innovation Commission Foundation of Shenzhen, No. JCYJ20190808141013454 and No. JCYJ20180305124827261; and Shenzhen Key Laboratory Foundation, No. ZDSYS20200811143757022.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Pei Zhu, MD, Doctor, Professor, Department of Urology, Shenzhen University General Hospital, No. 1098 Xueyuan Road, Shenzhen 518055, Guangdong Province, China.
Received: May 17, 2021
Peer-review started: May 17, 2021
First decision: June 15, 2021
Revised: June 17, 2021
Accepted: July 12, 2021
Article in press: July 12, 2021
Published online: September 16, 2021


Angiolipoma has been reported in many cases, and it often occurs in the skin of the trunk and limbs. However, angiolipoma in the scrotum is a rare disease with unknown etiology. This condition is difficult to diagnosis with other lumps in the scrotum.


A 32-year-old man presented to the urinary department with a history of an enlarged left scrotum with increasing discomfort for about 5 years. Physical examination revealed that there were a palpable mass measuring about 7.0 cm × 6.5 cm in the left scrotum, with smooth surfaces but without tenderness or adhesion to the skin. Ultrasound showed that there was a hyperechoic mass under the skin of the top scrotum, about 72 mm × 64 mm × 21 mm in size, with clear borders, uneven internal echo, and abundant blood flow signals. Serum human chorionic gonadotropin and alpha-fetoprotein were in normal level. Subcutaneous mass resection at the bottom of the left scrotum was performed under local anesthesia with 1% lidocaine. Postoperative pathological examination resulted in a diagnosis of subcutaneous angiolipoma of the scrotum. No evidence of recurrence was found at 6 mo after surgery and there were no complaints of discomfort.


Angiolipoma is an extremely rare type of benign tumor extremely rarely found in the scrotum, but needs to be considered when evaluating scrotal masses especially when the mass is solid. According to the characteristics of angiolipoma, surgical resection is the best treatment strategy and it is not prone to recurrence after resection.

Key Words: Angiolipoma in the scrotum, Ultrasound, Pathological diagnosis, Operation, Case report

Core Tip: Subcutaneous angiolipoma is a rare type of benign tumor extremely rarely found in the scrotum but needs to be considered when evaluating scrotal masses. We report a case of subcutaneous angiolipoma of the scrotum, and summarize its clinical manifestations and pathological characteristics to improve the understanding of this disease.


Angiolipomas are composed of mature adipose tissue and abnormally proliferating vascular tissue[1]. The condition was once considered a type of hamartoma but is now classified as a subtype of lipoma, and there is a widespread perception that it originates from the metaplastic transformation of pluripotent mesenchymal cells. Angiolipomas located in the scrotum are relatively rare, with only few case reports[2]. Here, we report a case of multiple non-infiltrating angiolipomas, including in the scrotum. The patient underwent surgical removal, and no evidence of recurrence was found 6 mo after surgery.

Chief complaints

A 32-year-old male patient presented due to a 5-year history of an enlarged left scrotum with increasing discomfort.

History of present illness

The patient had signs of discomfort, without abdominal pain, and swelling.

History of past illness

The patient was healthy and had no relevant history of disease.

Personal and family history

The patient had no personal and family history of malignancy.

Physical examinations

Physical examinations revealed a palpable subcutaneous mass measuring about 7.0 cm × 6.5 cm in the left scrotum, with tenderness (Figure 1). The left scrotum was enlarged, containing an oval-shaped mass with a smooth surface and no tenderness. Using a light transmission test, the testes on both sides were found to be palpable.

Figure 1
Figure 1 Presurgical view of the left scrotal mass.
Laboratory examinations

Laboratory findings were within normal limits. Serum human chorionic gonadotropin and alpha-fetoprotein were in normal level.

Imaging examinations

Color Doppler ultrasound of the scrotum, bilateral testes, and epididymis was performed, which revealed a subcutaneous hyperechoic mass in the left scrotum with a size of approximately 72 mm × 64 mm × 41 mm. The mass had a clear boundary, and the internal echo was uneven with visible sinusoids and strip-shaped blood flow signals. The mass was not connected to the abdominal cavity (Figure 2). No apparent abnormalities were observed in the other parts.

Figure 2
Figure 2 Colour Doppler ultrasound showing a hyperechoic mass under the skin of the left scrotum. The mass measures about 72 mm × 64 mm × 41 mm, with clear boundaries, uneven internal echo, sinusoids, and strip-shaped blood flow signals; it is not connected to the abdominal cavity.

According to the results of pathology, the tumor was diagnosed as subcutaneous angiolipoma (Figure 3).

Figure 3
Figure 3 Postoperative pathological examination. The mass is composed of mature adipose tissue, fibrous tissue, and blood vessels; no invasion was observed (haematoxylin and eosin staining, × 200 magnification).

The patient underwent left scrotal mass resection (Figure 4).

Figure 4
Figure 4 The size of the tumor-like tissue removed is about 68 mm × 79 mm × 39 mm.

After 4 d of treatment after the surgery, the patient was discharged. He was found to recover well at the 1-, 3-, and 6-mo follow-up after discharge.


Angiolipomas, first described by Bowen in 1912, account for 6%-17% of all lipomas[3]. They are benign mesenchymal tumors composed of lipoma tissue, capillaries, and stroma, with a vascular component of 15%-50%. This contrasts with the proportion of blood vessels in common lipomas, which is less than 10%[4]. Angiolipomas usually occur in teenagers and young adults between 20 and 25 years old, most commonly in the forearm (approximately two-thirds of cases), followed by the upper arm, thigh, and front abdominal wall, with a size of 1-4 cm. Men are more often affected than women[5]. Arenaz Bua found that 5% of the cases had a family heredity, and the specific inheritance pattern was uncertain. Tumours are often painful or tender and are most commonly seen in young men[6]. Another study found that adipose tissue tumours may be related to a history of trauma in addition to multiple familial lipomatosis and other genetic predispositions[7]. Clinical signs and symptoms are atypical and primarily manifest as multiple subcutaneous nodules, which may be accompanied by pain. Early lumps are small and often difficult to find because there are no obvious symptoms; when the lumps slowly increase in size, local symptoms of compression may occur.

We report the case of a 32-year-old man with an angiolipoma in the left scrotum. The left scrotum is an extremely rare site affected by angiolipomas. After reviewing the literature, we found that this is the first report of left scrotum angiolipoma with a length of more than 7 cm. Most para-testicular masses are benign, and lipomas account for approximately 90% of benign tumours in the para-testicular soft tissue[8]. The patient had no history of surgical resection, no history of trauma, and no family genetic history, and the pathological findings of this postoperative period were all angiolipomas. This case had unique characteristics in terms of location, size, management, and diagnosis.

Preoperative physical examinations cannot establish a diagnosis of angiolipomas, and ultrasound examination is the first choice of imaging modalities. Diagnosis must be confirmed by postoperative pathological examination. Therefore, the treatment of this disease should be based on surgery. A quick-frozen pathological examination during the operation should be performed to determine the nature of the disease. It should be distinguished from the lipomas or sarcomas, which have malignant or aggressive clinical courses.


Angiolipoma is a rare type of benign tumor extremely rarely found in the scrotum but needs to be considered when evaluating scrotal masses. Due to the economy and ease of use of ultrasound examinations, as well as the sensitivity to lesion location and size, it is the imaging test of choice for the characterisation of pathological masses in the scrotum and testes[9]. However, ultrasound is less specific in distinguishing between benign and malignant tumours[10]. Therefore, it is necessary to diagnose testicular angiolipoma through the histological evaluation of surgical specimens to determine the appropriate treatment plan.


We are grateful to the patient for providing relevant information and informed consent for publication of this case report.


Manuscript source: Unsolicited manuscript

Specialty type: Medicine, research and experimental

Country/Territory of origin: China

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P-Reviewer: Patel L S-Editor: Wang LL L-Editor: Wang TQ P-Editor: Li JH

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