Successful treatment of lichen amyloidosis coexisting with atopic dermatitis by dupilumab: Four case reports

Figure 4 Case 4. A and B: Erythema and a dense distribution of hard brown papules were seen on the patient’s back. Both calves showed a characteristic rippled pattern, which was most prominent on the anterolateral aspect of the right calf; C and D: After 16 wk of treatment, the papules on both calves became flat and the wavy pattern markedly disappeared, suggestive of diminished amyloid burden; E: Hyperkeratotic and hyperplastic epidermis as well as homogeneous pinkish materials in the dermal papilla were seen (hematoxylin & eosin staining, × 100); F: Crystal violet staining was positive for amyloid deposits (crystal violet staining, × 400). The arrow indicates amyloid deposits.