Intracranial large artery embolism due to carotid thrombosis caused by a neck massager: A case report

Abstract

BACKGROUND

There are few reported cases of intracranial large artery embolism due to carotid thrombosis caused by a neck massager. Herein we report such a case.

CASE SUMMARY

A 49-year-old woman presented with left limb weakness and dysarthria after a history of neck massage for 1 mo. Neurological examination showed left central facial paralysis and left hemiparesis with a National Institutes of Health Stroke Scale score of 12. Brain magnetic resonance imaging revealed restricted diffusion on diffusion-weighted imaging in the right parietal and temporal lobes. Computed tomography angiography (CTA) indicated M3 segment embolism of the right middle cerebral artery. Neck CTA revealed thrombosis of the bilateral common carotid arteries. Carotid ultrasound showed thrombosis in the bilateral common carotid arteries (approximately 2 cm below the proximal end of the carotid sinus), and contrast-enhanced ultrasound did not suggest enhancement. No hypertension, diabetes, heart disease, vasculitis, or thrombophilia was found after admission. After 1 wk of treatment with aspirin 200 mg and atorvastatin 40 mg, a carotid ultrasound reexamination showed that the thrombosis had significantly reduced.

CONCLUSION

Neck massager may cause carotid artery thrombosis.

Key Words: Neck massager; Carotid thrombosis formed; Intracranial large artery embolism; Stroke; Endothelial damage; Case report

Core Tip: It has been reported that stroke caused by a neck massager is mainly related to arterial dissection due to the tearing of the inner vessel. Herein we report a rare case of intracranial large artery embolism due to carotid thrombosis caused by a neck massager. Combined with the analysis of the cases indexed in PubMed, only one case of a free thrombus in the carotid artery has been reported, although the etiology is unclear. We found that an intracranial large artery embolism was due to carotid thrombosis caused by a neck massager, which was treated effectively by antiplatelet therapy. In the future, it may be necessary to study further and propose stricter quality management standards for massagers.

INTRODUCTION

The probability of stroke caused by a neck massager is 1/300–1/400000, which is mostly related to arterial dissection due to the tearing of the vascular inner layer (mainly involving the vertebral artery, followed by the carotid artery)[1-3]. Cerebral infarction caused by arterial embolism after a massager is rare[4,5].

A neck massager stimulates the neck according to the principle of pulsed microcurrents to promote blood circulation and alleviate fatigue. In this report, we describe an intracranial large artery embolism due to carotid thrombosis caused by a neck massager.

CASE PRESENTATION

Chief complaints

Left lower limb weakness for more than 5 h.

History of present illness

More than five hours prior, left lower limb weakness suddenly occurred in a 49-year-old female patient; the left upper limb could move autonomously, but the lower limb could only shift on the bed surface. She had slurred speech, no nausea or vomiting, limb twitching, and urinary incontinence. She was given thrombolytic therapy with alteplase (50 mg) at 11:50 am in another hospital, and her symptoms did not worsen after thrombolytic treatment.

History of past illness

The patient had no history of hypertension, diabetes, hyperlipidemia, heart disease, smoking, or drinking.

Personal and family history

The patient denied any family history of malignant tumors.

Physical examination

The patient’s vital signs were: Body temperature, 37.1 °C; blood pressure, 122/82 mmHg; heart rate, 82 beats per min; and respiratory rate, 18 breaths per min. The cardiopulmonary examination was normal. Her cognition seemed normal; her speech was a little vague; the neck showed soft passivity; the Kernig sign was negative; the pupils were symmetrical and 3 mm in diameter; the light reflex was normal; eye movement was normal; there was no nystagmus; bilateral hearing was symmetrical; bilateral nasolabial folds were symmetrical; and the tongue could be stuck out on request in the center.

Her left lower limb muscle strength was level 1, left upper limb muscle strength was level 5, right lower and upper limb muscle strength was level 5, and the tendon reflexes of the extremities were normal; the muscle tone of the extremities was normal; Babinski sign was positive on the left, but negative on the right; and bilateral acupuncture sensations and deep sensations were symmetrical. The bilateral finger-nose touch, rotation, heel, knee, and tibia tests were stable and accurate, and the closed eyes sign could not be combined. Her initial National Institutes of Health Stroke Scale (NIHSS) score was 4, the modified Rankin Scale (mRS) score was 4, and her water swallow test grade was 2.

Laboratory examinations

Laboratory results were normal except for the D-dimer level at 4410.0 μg/L. In addition, her thrombophilia genes were investigated, and the results suggested two risk factors: A 2 KB heterozygous mutation upstream of PAI-1 (NM_000602.5) and a homozygous missense mutation in MTHFR (NM_005957.5).

Imaging examinations

Computed tomography (CT) of the head showed no brain hemorrhage. CT angiography (CTA) revealed occlusion of the M3 segment of the right middle cerebral artery (MCA) (Figure 1A).

Figure 1 Image of an intracranial major artery embolism due to carotid artery thrombosis caused by a neck massager. A: Computed tomography angiography (CTA) revealed occlusion of the M3 segment of the right middle cerebral artery; B: Magnetic resonance imaging performed 24 h after hospitalization revealed multiple acute infarcts in the cortex of the right cerebral hemisphere; C and D: CTA showed thrombus formation in the distal segment of the right and left sides of the common carotid arteries.

ILLNESS EVOLUTION

Clinical symptoms and signs

The next day, the patient was transferred to the neurology ward; however, the left limb weakness worsened. The NIHSS score was 12, and the mRS was 4. After 4 d of treatment, the left limb weakness improved. At discharge, the patient had improved; her NIHSS score was 2, and her mRS score was 1.

Imaging examinations

Brain magnetic resonance imaging (MRI) showed limited diffusion on diffusion-weighted imaging of the right parietal and temporal lobes (Figure 1B). CTA (Figure 1C and D) and ultrasonography (Figure 2A and B) showed bilateral common carotid artery (CCA) thrombosis. Color Doppler carotid angiography (Figure 2C and D) and high-resolution enhanced MRI (Figure 2E) suggested bilateral CCA local thrombosis. On the eighth (Figure 3A and B) and 21^st (Figure 3C and D) day, carotid ultrasound was repeated, which revealed that the thrombosis was reduced in size.

Figure 2 Carotid ultrasound and high-resolution enhanced magnetic resonance imaging of an intracranial major artery embolism due to carotid artery thrombosis caused by a neck massager. A and B: Carotid ultrasound revealed that the right extent was approximately 12.8 mm × 3.8 mm, and the left extent was approximately 14.8 mm × 4.3 mm. Contrast-enhanced ultrasound showed that the thrombus was reduced on the fourth day, with no enhancement; C and D: The right extent was approximately 6.5 mm × 2.1 mm, and the left extent was approximately 6.4 mm × 2.4 mm; E: High-resolution enhanced magnetic resonance imaging of the neck vessels suggested a filling defect in the right common carotid arterie.

Figure 3 B-ultrasound of carotid thrombus changes after treatment. A and B: On the eighth day, carotid ultrasound showed that the thrombus was further reduced, with an extent of approximately 6.5 mm × 2.4 mm on the right and 5.3 mm × 2.1 mm on the left; C and D: Carotid ultrasound examination performed on the 14^th day revealed both right and left side common carotid arteries without thrombosis.

Review of the history

Four months prior, the patient started to use a neck physiotherapy instrument for 1 mo (Figure 4) (twice a day, 15 min each time) because of neck muscle tension. Pulse massager is different from ordinary roller massager, which is simple to relax muscles, while pulse massager is a massage method that simulates electric moxibustion. Pulse electric moxibustion was carried out by electromagnetic frequency of electrode. Deep into the skin of the human body, a pulse massager carries out acupoint massage of the strain points and stimulates the shoulder and neck pain area and acupoints, so as to dredge the cervical vertebra, break up the nodules, dilate blood vessels, promote blood circulation, and improve strain, dizziness, and neck pain.

Figure 4 Structure of the neck massager used by the patient.

FINAL DIAGNOSIS

Intracranial large artery embolism due to carotid thrombosis caused by a neck massager.

TREATMENT

The patient received intensive statin treatment (atorvastatin 40 mg).

Oral aspirin 200 mg and atorvastatin 40 mg daily were prescribed at discharge. After discharge, the aspirin was reduced to 100 mg once a day and the atorvastatin to 20 mg once a day.

OUTCOME AND FOLLOW-UP

After 6 mo of follow-up, there was no stroke recurrence, the patient’s NIHSS score was 1, and her mRS score was 1. No symptoms were aggravated, no complications occurred, and no adverse events were recorded. The patient is satisfied with the treatment and can now continue with normal life.

DISCUSSION

To our knowledge, this report is the first to document a stroke caused by carotid thrombosis due to a neck massager. The brain MRI of the patient showed multiple acute infarcts in the right cerebral cortex, similar to arterial embolization. The cranial CTA showed that the M3 segment of the upper trunk of the right MCA was occluded. Carotid ultrasound showed symmetrical thrombosis of the bilateral common carotid arteries. At the same time, other etiologies, such as cardiogenic, immune, infectious, and hematological diseases, were ruled out. After antiplatelet therapy, dynamic reexamination by carotid artery ultrasound showed that the thrombus had significantly reduced and eliminated 21 d after stroke onset. We believe that the neck massager destroyed the vascular endothelial cells in this patient, thus forming carotid artery thrombosis and causing an intracranial arterial embolism.

Cerebral infarction caused by neck massage is often secondary to vascular dissection[1-3]. Only one case of a free thrombus in the carotid artery has been reported, and the specific etiology is unclear[4]. Another case documented vertebral artery dissection after repetitive use of a handheld massage gun[5]. The literature has suggested that massager can make the blood in the carotid artery swirl[6]. Long-term changes in blood flow and acute injury of the artery may lead to changes in the structure of endothelial cells. The lipids exposed after plaque rupture activate platelets and the coagulation system to form thrombi, reducing the blood supply to the brain. In addition, endothelial damage may impact plaques on the arterial wall, causing them to break and fall off. Plaque shedding may lead to distal vascular embolism, which may cause vasospasm, intimal hyperplasia, and accelerated arteriosclerosis, resulting in intracranial arterial embolism[7].

The massager used by the patient in this report is based on the principle of pulsed microcurrents to stimulate local muscles and acupoints by fixing electrodes in the bilateral anterior cervical regions. Carotid and contrast-enhanced ultrasound in this patient suggested that the intima was intact, and the evidence for plaque rupture was insufficient. The possibility of endothelial damage was considered, which may be related to her mutations in MTHFR[8].

The treatment of carotid artery dissection may include antiplatelet therapy, anticoagulation therapy, or surgical treatment according to the incidence, clinical symptoms, and vascular conditions[9]. Emergency endovascular treatment may be selected for patients with acute intracranial large artery occlusion and hypoperfusion[10]. However, the intracranial occlusive segment of this patient was the M3 segment of the MCA, and there was no indication for emergency treatment. Carotid artery thrombosis is usually caused by atherosclerosis or carotid artery dissection; however, there is no clear guidance on drug treatment[11]. The patient's clinical symptoms improved after antiplatelet therapy, and the thrombus disappeared 21 d later, indicating that antiplatelet treatment was effective.

This patient had a stroke after starting to use a neck massager for 1 mo. Bilateral symmetrical thrombus signals occurred at the location of the CCA stimulated by the electric pulse, and the local intima was intact. The thrombus disappeared 21 d after antiplatelet treatment. The development of the thrombus was considered to be related to local endothelial injury after electric pulse stimulation. Different electric pulse frequencies may have varying effects on endothelial cells, and further research is needed to explore a more suitable safety frequency for users and establish a better approach to evaluating the safety of massagers.

The limitation of this case is that although the mechanism of intimal injury is proposed through ultrasound findings, there is no further pathology confirmation. In the future, more research is needed to find a safe massage power and formulate stricter quality management standards.

CONCLUSION

Neck massage may cause carotid artery thrombosis.

ACKNOWLEDGEMENTS

We would like to thank the patient and her family for their informed cooperation and support in our work.